香豆素与西咪替丁联合治疗晚期恶性黑色素瘤。一项II期研究。
Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study.
作者信息
Pedersen L, Rose C, Langvad E
出版信息
Cancer Immunol Immunother. 1987;24(2):178-9. doi: 10.1007/BF00205597.
Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma. Induction therapy with coumarin 100 mg daily was given for 8 weeks, whereupon cimetidine 1000 mg daily was added. No patients had been previously treated with cytotoxic drugs, and all patients had a good performance status. In 16 patients progressive disease was observed, and only 1 patient experienced no change in condition, lasting 30 weeks. We conclude that treatment with this schedule of coumarin and cimetidine is without effect in advanced malignant melanoma.
对17例晚期恶性黑色素瘤患者进行了香豆素与西咪替丁免疫刺激疗法的评估。给予患者每日100毫克香豆素进行诱导治疗，持续8周，随后添加每日1000毫克西咪替丁。此前所有患者均未接受过细胞毒性药物治疗，且所有患者的身体状况良好。16例患者病情进展，只有1例患者病情未发生变化，持续了30周。我们得出结论，这种香豆素与西咪替丁的治疗方案对晚期恶性黑色素瘤无效。
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