Lee Yeji, Song Young Seop, Phi Ji Hoon, Kim In-One, Kim Keewon
Department of Rehabilitation Medicine, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.
Seoul Gangnam Rehabilitation Clinic, 227 Seolleung-Ro, Gangnam-gu, Seoul, 06275, Republic of Korea.
Childs Nerv Syst. 2023 Mar;39(3):811-814. doi: 10.1007/s00381-022-05674-6. Epub 2022 Nov 2.
Toxocariasis is a common parasitic infection worldwide. Although it can present as several clinical syndromes, neurological manifestation is rare. Only a few reports are available on spinal cord involvement of toxocariasis. We report a case that presented with gait disturbance due to progressive lower limb spasticity. The patient had had visceral toxocariasis infection 8 years before. A spine magnetic resonance image (MRI) showed syringomyelia along the entire thoracic cord with small nodular enhancing lesions in the mid-portion of the syrinx, which led to the suspicion of ependymoma. Surgical mass removal was performed. However, histopathological examination of the mass did not show any malignant cells; instead, there were numerous axonal retraction balls with an eosinophilic granular body-like appearance. The serum antibody titer against toxocariasis was borderline high. Taken together, these observations led to a diagnosis of Toxocara infection, and the patient was treated with albendazole.
To the best of our knowledge, this is the first case report of tumor-like spinal toxocariasis involving extensive lesions. A solid enhancing mass with accompanied syrinx and hemorrhage might be a Toxocara infection. It can easily be diagnosed with serologic tests and simply be treated with oral albendazole if suspected.
弓蛔虫病是一种全球常见的寄生虫感染。尽管它可表现为多种临床综合征,但神经系统表现较为罕见。关于弓蛔虫病累及脊髓的报道仅有少数几例。我们报告一例因进行性下肢痉挛导致步态障碍的病例。该患者8年前曾有内脏弓蛔虫感染。脊柱磁共振成像(MRI)显示整个胸段脊髓存在空洞症,空洞中部有小结节状强化病灶,这引发了对室管膜瘤的怀疑。遂进行了肿物切除手术。然而,肿物的组织病理学检查未发现任何恶性细胞;相反,有许多呈嗜酸性颗粒体样外观的轴突回缩球。抗弓蛔虫病的血清抗体滴度处于临界高水平。综合这些观察结果,诊断为弓蛔虫感染,患者接受了阿苯达唑治疗。
据我们所知,这是首例关于累及广泛病变的肿瘤样脊髓弓蛔虫病的病例报告。伴有空洞和出血的实性强化肿物可能是弓蛔虫感染。如果怀疑,通过血清学检测很容易诊断,且仅用口服阿苯达唑即可简单治疗。