Boom B W, Out-Luiting C J, Baldwin W M, Westedt M L, Daha M R, Vermeer B J
Arch Dermatol. 1987 Sep;123(9):1192-5.
The presence of the membrane attack complex of complement (MAC) was studied by a two-step immunofluorescence method in 15 patients with leukocytoclastic vasculitis of the skin, using an antibody against MAC neoantigen. Perivascular deposits of MAC were present in 13 specimens of lesional skin and only two specimens of clinically uninvolved skin, suggesting a possible pathogenetic role for MAC in the development of a skin lesion. Control studies were performed on the clinically normal skin of 15 individuals (11 patients with various nonbullous skin diseases and four healthy volunteers) and on skin lesions of seven patients with inflammatory skin diseases. In the clinically normal skin of only one patient, perivascular deposits of MAC were detected. This patient had rheumatoid arthritis and a cutaneous eruption due to the administration of aurothioglucose. We conclude that the activation of the terminal components of the complement system may play an important role in the formation of lesions in leukocytoclastic vasculitis of the skin, but is not an indispensable condition.
采用两步免疫荧光法，使用抗补体膜攻击复合物（MAC）新抗原的抗体，对15例皮肤白细胞破碎性血管炎患者的MAC存在情况进行了研究。MAC的血管周围沉积物存在于13例病变皮肤标本中，而仅在2例临床未受累皮肤标本中出现，提示MAC在皮肤病变发展中可能具有致病作用。对15名个体（11例患有各种非大疱性皮肤病的患者和4名健康志愿者）的临床正常皮肤以及7例炎症性皮肤病患者的皮肤病变进行了对照研究。仅在1例患者的临床正常皮肤中检测到MAC的血管周围沉积物。该患者患有类风湿关节炎，因注射金硫葡萄糖而出现皮肤疹。我们得出结论，补体系统终末成分的激活可能在皮肤白细胞破碎性血管炎病变形成中起重要作用，但并非必不可少的条件。
