Department of Physiology, Behbahan Faculty of Medical Sciences, Behbahan, Iran.
Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
J Renin Angiotensin Aldosterone Syst. 2022 Oct 22;2022:9800838. doi: 10.1155/2022/9800838. eCollection 2022.
Renal ischemia-reperfusion injury (RIRI) is a sequence of complicated events that is defined as a reduction of the blood supply followed by reperfusion. RIRI is the leading cause of acute kidney injury (AKI). Among the diverse mediators that take part in RIRI-induced AKI, the renin-angiotensin system (RAS) plays an important role via conventional (angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptor (ATR)) and nonconventional (ACE2, Ang 1-7, Ang 1-9, AT receptor (ATR), and Mas receptor (MasR)) axes. RIRI alters the balance of both axes so that RAS can affect RIRI-induced AKI. In overall, the alteration of Ang II/ATR and AKI by RIRI is important to consider. This review has looked for the effects and interactions of RAS activities during RIRI conditions.
肾缺血再灌注损伤（RIRI）是一系列复杂事件，定义为血液供应减少后再灌注。RIRI 是急性肾损伤（AKI）的主要原因。在参与 RIRI 诱导的 AKI 的多种介质中，肾素-血管紧张素系统（RAS）通过传统（血管紧张素原、肾素、血管紧张素转换酶（ACE）、血管紧张素（Ang）II 和 Ang II 型 1 受体（ATR））和非传统（ACE2、Ang 1-7、Ang 1-9、AT 受体（ATR）和 Mas 受体（MasR））轴发挥重要作用。RIRI 改变了两个轴的平衡，从而 RAS 可以影响 RIRI 诱导的 AKI。总的来说，RIRI 对 Ang II/ATR 和 AKI 的改变是需要考虑的。本综述寻找了 RAS 活性在 RIRI 条件下的作用和相互作用。
