Zhang Nan, Gao Yan, Sheng Kangjia, Jing Wanghui, Xu Xianliang, Bao Tao, Wang Sicen
School of Pharmacy, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, 999078, China.
J Pharm Anal. 2022 Oct;12(5):791-800. doi: 10.1016/j.jpha.2022.06.004. Epub 2022 Jun 14.
In this study, ecofriendly and economic carboxy-terminated plant fibers (PFs) were used as adsorbents for the effective in-syringe solid phase extraction (IS-SPE) of fluoroquinolone (FQ) residues from water. Based on the thermal esterification and etherification reaction of cellulose hydroxy with citric acid (CA) and sodium chloroacetate in aqueous solutions, carboxy groups grafted onto cotton, cattail, and corncob fibers were fabricated. Compared with carboxy-terminated corncob and cotton, CA-modified cattail with more carboxy groups showed excellent adsorption capacity for FQs. The modified cattail fibers were reproducible and reusable with relative standard deviations of 3.2%-4.2% within 10 cycles of adsorption-desorption. A good extraction efficiency of 71.3%-80.9% was achieved after optimizing the extraction condition. Based on carboxylated cattail, IS-SPE coupled with ultra-performance liquid chromatography with a photodiode array detector was conducted to analyze FQs in environmental water samples. High sensitivity with limit of detections of 0.08-0.25 μg/L and good accuracy with recoveries of 83.8%-111.7% were obtained. Overall, the simple and environment-friendly modified waste PFs have potential applications in the effective extraction and detection of FQs in natural waters.
在本研究中，采用环境友好且经济的羧基封端植物纤维（PFs）作为吸附剂，用于从水中有效在线固相萃取（IS-SPE）氟喹诺酮（FQ）残留。基于纤维素羟基在水溶液中与柠檬酸（CA）和氯乙酸钠的热酯化和醚化反应，制备了接枝到棉、香蒲和玉米芯纤维上的羧基。与羧基封端的玉米芯和棉相比，具有更多羧基的CA改性香蒲对FQ表现出优异的吸附能力。改性香蒲纤维具有可重现性和可重复使用性，在10次吸附-解吸循环内相对标准偏差为3.2%-4.2%。优化萃取条件后，萃取效率良好，达到71.3%-80.9%。基于羧化香蒲，采用IS-SPE结合配备光电二极管阵列检测器的超高效液相色谱法对环境水样中的FQ进行分析。检测限为0.08-0.25μg/L，灵敏度高，回收率为83.8%-111.7%，准确度良好。总体而言，简单且环境友好的改性废弃PFs在天然水体中FQ的有效萃取和检测方面具有潜在应用。
