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水相兼容的二氧化硅负载三氟乙酸铁和三氯乙酸铁：作为用于无溶剂绿色合成六氢喹啉-3-甲酰胺的卓越且可循环的路易斯酸催化剂。

Water compatible silica supported iron trifluoroacetate and trichloroacetate: as prominent and recyclable Lewis acid catalysts for solvent-free green synthesis of hexahydroquinoline-3-carboxamides.

作者信息

Gholap Dnyaneshwar Purushottam, Huse Ramdas, Dipake Sudarshan, Lande M K

机构信息

Department of Chemistry, Dr Babasaheb Ambedkar Marathwada University Aurangabad Maharashtra India

出版信息

RSC Adv. 2023 Aug 4;13(34):23431-23448. doi: 10.1039/d3ra03542e.

DOI:10.1039/d3ra03542e
PMID:37546227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10401520/
Abstract

Silica supported iron trifluoroacetate and iron trichloroacetate green Lewis acid catalysts were developed by a novel, cheap, environment-friendly approach and utilized in the synthesis of hexahydroquinoline-3-carboxamide derivatives. The structure and morphology of the prepared Lewis acid catalysts were studied by FTIR, PXRD, FE-SEM, HR-TEM, EDX, BET, TGA and NH-TPD techniques. The present catalysts shows maximum conversion efficiency in hexahydroquinoline-3-carboxamide derivatives synthesis at 70 °C in solvent free reaction condition with best product yield in a short reaction time. Both catalysts are reusable and simple to recover, and perform meritoriously in water as well as in a variety of organic solvents. The key advantages of the current synthetic route are permitting of a variety of functional groups, quick reaction time, high product yield, mild reaction condition, recyclability of catalyst and solvent-free green synthesis. This makes it more convenient, economic and environmentally beneficial.

摘要

通过一种新颖、廉价且环境友好的方法制备了二氧化硅负载的三氟乙酸铁和三氯乙酸铁绿色路易斯酸催化剂，并将其用于六氢喹啉-3-甲酰胺衍生物的合成。通过傅里叶变换红外光谱（FTIR）、粉末X射线衍射（PXRD）、场发射扫描电子显微镜（FE-SEM）、高分辨率透射电子显微镜（HR-TEM）、能谱分析（EDX）、比表面积分析（BET）、热重分析（TGA）和氨程序升温脱附（NH-TPD）技术对所制备的路易斯酸催化剂的结构和形貌进行了研究。在无溶剂反应条件下，当前催化剂在70℃合成六氢喹啉-3-甲酰胺衍生物时显示出最大的转化效率，且在短反应时间内具有最佳的产物收率。两种催化剂均可重复使用且易于回收，在水以及多种有机溶剂中均表现出色。当前合成路线的关键优势在于允许多种官能团存在、反应时间短、产物收率高、反应条件温和、催化剂可循环使用以及无溶剂绿色合成。这使其更加方便、经济且对环境有益。

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