基于人群的研究：精脒血浆水平与大脑衰老的关联。
Association of spermidine plasma levels with brain aging in a population-based study.
机构信息
Department of Neurology, University Medicine Greifswald, Greifswald, Germany.
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
出版信息
Alzheimers Dement. 2023 May;19(5):1832-1840. doi: 10.1002/alz.12815. Epub 2022 Nov 2.
INTRODUCTION
Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD).
METHODS
Data from 659 participants (age range: 21-81 years) of the population-based Study of Health in Pomerania TREND were included. We investigated the association between spermidine plasma levels and markers of brain aging (hippocampal volume, AD score, global cortical thickness [CT], and white matter hyperintensities [WMH]).
RESULTS
Higher spermidine levels were significantly associated with lower hippocampal volume (ß = -0.076; 95% confidence interval [CI]: -0.13 to -0.02; q = 0.026), higher AD score (ß = 0.118; 95% CI: 0.05 to 0.19; q = 0.006), lower global CT (ß = -0.104; 95% CI: -0.17 to -0.04; q = 0.014), but not WMH volume. Sensitivity analysis revealed no substantial changes after excluding participants with cancer, depression, or hemolysis.
DISCUSSION
Elevated spermidine plasma levels are associated with advanced brain aging and might serve as potential early biomarker for AD and vascular brain pathology.
简介
补充亚精胺可能有助于健康衰老，但组织中亚精胺水平升高被认为是阿尔茨海默病（AD）的一个指标。
方法
本研究纳入了基于人群的德国波美拉尼亚健康趋势研究中 659 名参与者（年龄范围：21-81 岁）的数据。我们调查了血浆中亚精胺水平与大脑老化标志物（海马体积、AD 评分、全脑皮质厚度[CT]和脑白质高信号[WMH]）之间的关系。
结果
较高的亚精胺水平与较低的海马体积（β=-0.076；95%置信区间：-0.13 至-0.02；q=0.026）、较高的 AD 评分（β=0.118；95%置信区间：0.05 至 0.19；q=0.006）、较低的全脑 CT（β=-0.104；95%置信区间：-0.17 至-0.04；q=0.014）显著相关，但与 WMH 体积无关。敏感性分析显示，排除癌症、抑郁或溶血患者后，结果没有实质性变化。
讨论
血浆中亚精胺水平升高与大脑老化有关，可能是 AD 和血管性脑病理的潜在早期生物标志物。
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