Miller R H, Linet M S, Van Natta M L, McCaffrey L D, Humphrey R L
Arch Intern Med. 1987 Sep;147(9):1614-7.
Serum protein electrophoresis (SPEP) data obtained at diagnosis were available for 98 of 342 patients with chronic lymphocytic leukemia (CLL) identified in a population-based case-control epidemiologic study. Patients tested with SPEP at diagnosis were significantly younger, more likely to have lymphadenopathy, and more likely to have had their conditions diagnosed at a university hospital than those not tested. Four categories of electrophoretic patterns were identified: normal (N = 56), hypogammaglobulinemia (N = 28), hypergammaglobulinemia (N = 11), and monoclonal gammopathy (N = 3). A higher proportion of those with hypergammaglobulinemia were black, and patients with hypergammaglobulinemia and monoclonal gammopathy were more likely to die within the first year following diagnosis than patients in the other SPEP groups. No association was found, however, between SPEP pattern and a clinical staging classification for CLL. These findings suggest that SPEP may be a useful adjunct in categorizing possible subtypes of CLL and developing future clinical staging classifications.
在一项基于人群的病例对照流行病学研究中确诊的342例慢性淋巴细胞白血病（CLL）患者中，98例患者有诊断时获得的血清蛋白电泳（SPEP）数据。诊断时接受SPEP检测的患者比未接受检测的患者明显更年轻，更有可能出现淋巴结病，并且更有可能在大学医院确诊病情。确定了四类电泳模式：正常（N = 56）、低丙种球蛋白血症（N = 28）、高丙种球蛋白血症（N = 11）和单克隆丙种球蛋白病（N = 3）。高丙种球蛋白血症患者中黑人比例更高，与其他SPEP组的患者相比，高丙种球蛋白血症和单克隆丙种球蛋白病患者在诊断后的第一年内死亡的可能性更大。然而，未发现SPEP模式与CLL的临床分期分类之间存在关联。这些发现表明，SPEP可能是对CLL可能的亚型进行分类以及制定未来临床分期分类的有用辅助手段。
