多不饱和脂肪酸治疗急性缓解型多发性硬化症
Polyunsaturated fatty acids in treatment of acute remitting multiple sclerosis.
作者信息
Bates D, Fawcett P R, Shaw D A, Weightman D
出版信息
Br Med J. 1978 Nov 18;2(6149):1390-1. doi: 10.1136/bmj.2.6149.1390.
Abstract
One hundred and sixteen patients with acute remitting multiple sclerosis (MS) took part in a double-blind controlled trial of treatment with polyunsaturated fatty acids and were randomly allocated to one of four groups. Two groups received linoleic acid, one alone as a spread and one with gamma-linolenic acid in capsules (Naudicelle); and two control groups received oleic acid, one as a spread and one in capsules. Rates of clinical deterioration and frequencies of attacks were not significantly different between treated and control groups. Exacerbations were shorter and less severe in patients receiving a high dose of linoleic acid than in controls, but those receiving a lower dose--that is, Naudicelle--showed no such difference. Thus supplementing the diet with 20 g linoleic acid marginally affected the duration and severity of relapses of MS but had no effect on overall disability. The dose of Naudicelle used provided insufficient supplementation.
摘要
116例急性缓解型多发性硬化症（MS）患者参与了一项关于多不饱和脂肪酸治疗的双盲对照试验，并被随机分配到四组中的一组。两组接受亚油酸治疗，一组单独使用亚油酸作为涂抹剂，另一组将亚油酸与γ-亚麻酸装入胶囊（诺丽可）服用；两组对照组接受油酸治疗，一组使用油酸作为涂抹剂，另一组将油酸装入胶囊服用。治疗组和对照组之间的临床恶化率和发作频率没有显著差异。接受高剂量亚油酸治疗的患者病情加重的时间比对照组短且程度较轻，但接受低剂量（即诺丽可）治疗的患者则没有这种差异。因此，在饮食中补充20克亚油酸对MS复发的持续时间和严重程度有轻微影响，但对整体残疾状况没有影响。所使用的诺丽可剂量提供的补充不足。
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