Field E J, Shenton B K
Acta Neurol Scand. 1975 Aug;52(2):121-36. doi: 10.1111/j.1600-0404.1975.tb05766.x.
Using the macrophage electrophoretic mobility (MEM) test, the in vitro effects of oleic, linoleic and arachidonic acid, as well as Naudicell oil and methyl gamma-linolenate, on lymphocyte response to various antigens (PPD, thyroid antigen and EF) were studied in patients with mutiple sclerosis, patients with other neurological diseases, and in normal subjects. In all three groups, linoleic and arachidonic acid showed a significant inhibition; the latter was greater than the former, when tested at physiological concentrations, suggesting that unsaturated fatty acids may exert an immunoregulatory effect in vivo. The methylester of gamma-linolenate is the most powerful suppressing agent yet tested. The inhibitory activity of linoleic and arachidonic acids was consistently greater in MS than in other subjects and forms the basis of an in vitro test for the disease. The possible relationship of these findings to widespread alterations in the fatty acid composition of the tissues and to the pathogenesis of MS is discussed.
利用巨噬细胞电泳迁移率（MEM）试验，研究了油酸、亚油酸、花生四烯酸以及诺迪康油和γ-亚麻酸甲酯对多发性硬化症患者、其他神经系统疾病患者及正常受试者淋巴细胞对各种抗原（结核菌素纯蛋白衍生物、甲状腺抗原和EF）反应的体外影响。在所有三组中，亚油酸和花生四烯酸均表现出显著抑制作用；在生理浓度下进行测试时，后者的抑制作用大于前者，这表明不饱和脂肪酸可能在体内发挥免疫调节作用。γ-亚麻酸甲酯是目前测试过的最有效的抑制剂。亚油酸和花生四烯酸的抑制活性在多发性硬化症患者中始终高于其他受试者，这构成了该疾病体外检测的基础。文中还讨论了这些发现与组织脂肪酸组成广泛变化以及多发性硬化症发病机制之间的可能关系。
