Bobrik I I, Shevchenko E A, Alimov G A
Arkh Anat Gistol Embriol. 1987 Jun;92(6):43-6.
Structure of endotheliocytes of the human liver sinusoids during 4-5-9 months of intrauterine development has been studied electron microscopically. At early stages of embryogenesis the liver sinusoids are covered with continuous endothelium. As cytodifferentiation progresses, formation of zonality in cytoplasm of endotheliocytes is observed. In the most thinned parts of cytoplasm single fenestrae, situating irregularly appear. As the fetus is growing, the number of diafragmented fenestrae increases their arrangement becomes more regular; together with accidental, claster arrangement of the fenestrae is observed. Open intra- and intercellular fenestrae of endotheliocytes appear in the second half of the intrauterine development. For endotheliocytes of the fetal liver sinusoids presence of transitory migrational pores is specific; they are maximally thinned areas of endotheliocytic cytoplasm, that emerge at the moment of diapedesis of the blood formed elements across the endothelial lining. High tempo of histogenesis is specific for endothelium of the liver sinusoids; the endothelium of a continuous type differentiates into the specialized--sinusoid endothelium.
运用电子显微镜对人类肝脏窦状隙内皮细胞在子宫内发育4至5至9个月期间的结构进行了研究。在胚胎发生的早期阶段，肝脏窦状隙被连续的内皮所覆盖。随着细胞分化的进展，可观察到内皮细胞胞质中出现分区现象。在胞质最薄的部分，不规则分布着单个窗孔。随着胎儿的生长，有隔膜窗孔的数量增加，其排列变得更加规则；同时还观察到窗孔的偶然、簇状排列。内皮细胞的细胞内和细胞间开放窗孔出现在子宫内发育的后半期。胎儿肝脏窦状隙内皮细胞存在短暂的迁移孔是其特点；它们是内皮细胞胞质的最薄区域，在血液有形成分穿过内皮衬里进行血细胞渗出时出现。肝脏窦状隙内皮的组织发生速度快是其特点；连续型内皮分化为特化的——窦状隙内皮。
