Bobrik I I, Bogdanova T I, Debelenko L V
Arkh Anat Gistol Embriol. 1988 Feb;94(2):24-8.
By means of transmissive electron microscopy the adrenals have been studied in 25 human embryos and fetuses at the age of 6-36 weeks. Certain stages have been revealed in formation of the adrenal cortex microcirculatory bed. In 6-7-week-old embryos (period of diffuse protocapillary bed) endothelial structure and mesenchymal cells, surrounding the adrenal anlage, resemble one another. A distinguished feature of the endothelium is regularly revealed desmosomes and large vacuoles, often found in cytoplasm of endotheliocytes. In 8-12-week-old fetuses (period when the organospecific microcirculatory bed is forming) sinusoid capillaries differentiate in the internal zone of the adrenal cortex; in endothelium fenestrae, "hatches", "locks" are revealed, the capillary basal membrane is formed. During subsequent time of the intrauterine development perfection of the microcirculatory pathways in the adrenals takes place, the arteriolar link of the subcapsular layer including. By the time of birth morphofunctional maturity of the microcirculatory bed in the adrenal cortex is noted.
通过透射电子显微镜，对25例6至36周龄的人类胚胎和胎儿的肾上腺进行了研究。肾上腺皮质微循环床的形成过程中呈现出某些阶段。在6至7周龄的胚胎（弥漫性原始毛细血管床期），肾上腺原基周围的内皮结构和间充质细胞彼此相似。内皮细胞的一个显著特征是经常可见桥粒和大液泡，它们常存在于内皮细胞的细胞质中。在8至12周龄的胎儿（器官特异性微循环床形成期），肾上腺皮质内带出现窦状毛细血管；在内皮细胞中可见窗孔、“开口”、“锁”，毛细血管基膜形成。在随后的子宫内发育过程中，肾上腺的微循环途径不断完善，包括被膜下层的小动脉连接。到出生时，肾上腺皮质微循环床已达到形态功能成熟。
