Bobrik I I, Morin M V, Shevchenko E A, Cherkasov V G, Parakhin A I
Arkh Anat Gistol Embriol. 1985 Dec;89(12):32-7.
By means of light and electron microscopy, the most general mechanisms of formation and development of primary blood microvessels in functionally different organs (adenohypophysis, thyroid, thymus, liver, spleen, small and large intestine) have been studied in human embryos 4-8 weeks of age. Ultrastructure of cells in the extra- and intraorganic mesenchyme is described; to the latter belongs the leading role in organization the pathways of the prevascular microcirculation. The primary microvessels are formed as a result of canalization of the intercellular clefts, lining with mesenchymal cells, that gradually transfer into primordial endotheliocytes. Basing on ultrastructural analysis, certain stages of differentiation of protocapillary endotheliocytes have been defined and described in different organs. The change of the prevascular microcirculation into the intraorganic protocapillary bed (the primary blood bed) is an essential and necessary stage of the organogenesis.
通过光学显微镜和电子显微镜，对4至8周龄人类胚胎中功能不同器官（腺垂体、甲状腺、胸腺、肝脏、脾脏、小肠和大肠）内初级血液微血管形成和发育的最普遍机制进行了研究。描述了器官外和器官内间充质中细胞的超微结构；后者在组织血管前微循环途径中起主导作用。初级微血管是由细胞间裂隙管道化形成的，裂隙内衬间充质细胞，这些细胞逐渐转变为原始内皮细胞。基于超微结构分析，已确定并描述了不同器官中原毛细血管内皮细胞分化的某些阶段。血管前微循环转变为器官内原毛细血管床（初级血床）是器官发生的一个重要且必要的阶段。
