California Safe Cosmetics Program, California Department of Public Health, Richmond, CA, USA.
Southwest Research Institute, San Antonio, TX, USA.
J Expo Sci Environ Epidemiol. 2022 Nov;32(6):864-876. doi: 10.1038/s41370-022-00485-y. Epub 2022 Nov 2.
Personal care products (PCPs) may contain chemicals associated with adverse health effects. Prior studies found differences in product use by race/ethnicity and suggest some women are disproportionately exposed to chemicals of concern (CoCs).
We quantified chemicals linked to cancer, reproductive or developmental harm, or endocrine disruption in PCPs used by women of color.
We documented PCPs in stores frequented by Black, Latina, and Vietnamese women in their communities in California and CoCs on ingredient labels of 546 unique hair, skin, makeup, nail, deodorant/perfume, and intimate care products. Community partners chose 31 products for a combined targeted and suspect screen (National Institute of Standards and Technology mass spectral library search) two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOFMS) analysis to detect chemicals not on ingredient labels.
We found that 65% of labels included CoCs, and 74% of labels had undisclosed ingredients listed as "fragrance." The most prevalent chemicals were parabens, cyclosiloxanes, and formaldehyde releasers. GCxGC-TOFMS found additional CoCs, including fragrances, solvents, preservatives, ultraviolet filters, and contaminants.
These findings contribute to awareness of potentially hazardous chemicals in PCPs, can help estimate disparities in chemical exposure, and complement research on health inequities due to chemical exposures from various contributors.
This study is one of the first detailed assessments of chemicals of concern found in various types of PCPs used by several racial/ethnic groups. We found that over half of the 546 products selected by community partners as marketed to and/or used by them contained ingredients linked to cancer, reproductive or developmental harm, or endocrine disruption. Laboratory analysis identified additional chemicals in a subset of products, including unlabeled fragrance chemicals and contaminants. Elucidating exposures to chemicals in PCPs is important for risk assessment and health inequity research.
个人护理产品（PCP）可能含有与不良健康影响相关的化学物质。先前的研究发现，不同种族/族裔的产品使用情况存在差异，并表明一些女性不成比例地接触到了令人关注的化学物质（CoC）。
我们量化了 PCP 中与癌症、生殖或发育损害或内分泌干扰相关的化学物质，这些 PCP 是有色人种女性使用的。
我们记录了加利福尼亚州社区中黑人、拉丁裔和越南裔女性经常光顾的商店中使用的 PCP，并记录了 546 种独特的头发、皮肤、化妆品、指甲、除臭剂/香水和私密护理产品的成分标签上的 CoC。社区合作伙伴选择了 31 种产品进行组合靶向和可疑筛选（美国国家标准与技术研究院质谱库搜索）二维气相色谱飞行时间质谱（GCxGC-TOFMS）分析，以检测成分标签上未列出的化学物质。
我们发现 65%的标签包含 CoC，74%的标签将未公开的成分列为“香料”。最常见的化学物质是对羟基苯甲酸酯、环硅氧烷和甲醛释放剂。GCxGC-TOFMS 发现了其他 CoC，包括香料、溶剂、防腐剂、紫外线过滤器和污染物。
这些发现有助于提高对 PCP 中潜在有害化学物质的认识，可以帮助估计化学物质暴露的差异，并补充因各种来源的化学物质暴露导致的健康不平等研究。
本研究是首次详细评估了几种种族/族裔群体使用的各种类型 PCP 中发现的 CoC。我们发现，社区合作伙伴选择的 546 种产品中有超过一半的产品含有与癌症、生殖或发育损害或内分泌干扰相关的成分。实验室分析在产品的一部分中发现了其他化学物质，包括未标记的香料化学物质和污染物。阐明 PCP 中化学物质的暴露情况对于风险评估和健康不平等研究很重要。
