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梅克尔憩室闪烁扫描术:技术、表现及诊断陷阱

Meckel diverticulum scintigraphy: technique, findings and diagnostic pitfalls.

作者信息

Aboughalia Hassan A, Cheeney Safia H E, Elojeimy Saeed, Blacklock Lisa C, Parisi Marguerite T

机构信息

Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA, 98195, USA.

Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA.

出版信息

Pediatr Radiol. 2023 Mar;53(3):493-508. doi: 10.1007/s00247-022-05527-z. Epub 2022 Nov 3.

DOI:10.1007/s00247-022-05527-z
PMID:36323958
Abstract

Meckel diverticulum, the most common congenital anomaly of the gastrointestinal tract, results from the aberrant involution of the omphalomesenteric duct and accounts for more than 50% of unexplained lower gastrointestinal bleeding in the pediatric population. The most accurate imaging tool to identify a Meckel diverticulum containing ectopic gastric mucosa is the Technetium-99m pertechnetate Meckel scan, a scintigraphic study with a reported accuracy of 90% in the pediatric population. In addition to depicting a Meckel diverticulum with ectopic gastric mucosa, careful attention to the normal biodistribution of the radiotracer can lead to the identification of unexpected pathology with implications for patient management. This article serves to review the embryological origin and anatomical features of Meckel diverticulum, highlight the role of scintigraphy in evaluating Meckel diverticulum, and discuss the proper imaging technique when performing this test. We will focus on pitfalls that can lead to an erroneous diagnosis as well as incidental findings that can affect patient management.

摘要

梅克尔憩室是胃肠道最常见的先天性异常,由卵黄管异常退化引起,在儿童不明原因下消化道出血中占比超过50%。识别含有异位胃黏膜的梅克尔憩室最准确的成像工具是锝-99m高锝酸盐梅克尔扫描,这是一项闪烁扫描研究,据报道在儿童人群中的准确率为90%。除了描绘含有异位胃黏膜的梅克尔憩室外,仔细关注放射性示踪剂的正常生物分布可发现意外病变,从而影响患者的管理。本文旨在回顾梅克尔憩室的胚胎起源和解剖特征,强调闪烁扫描在评估梅克尔憩室中的作用,并讨论进行此项检查时的正确成像技术。我们将重点关注可能导致错误诊断的陷阱以及可能影响患者管理的偶然发现。

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[Detection of ectopic gastric mucosa in Meckel's diverticulum by means of scintigraphy with 99mTc-pertechnetate in a 24-year old man].[一名24岁男性通过99m锝高锝酸盐闪烁扫描术检测梅克尔憩室中的异位胃黏膜]
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Diagnostic accuracy of [ Tc]pertechnetate scintigraphy in pediatric patients with suspected Meckel's diverticulum: a 12-year, monocentric, retrospective experience.锝[Tc]高锝酸盐闪烁扫描术对疑似梅克尔憩室患儿的诊断准确性:一项为期12年的单中心回顾性研究经验
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本文引用的文献

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Meckel's diverticulum diagnosed by double-balloon enteroscopy: A single-center retrospective study in Taiwan.经双气囊小肠镜诊断的梅克尔憩室:台湾一项单中心回顾性研究
JGH Open. 2021 Dec 29;6(1):63-68. doi: 10.1002/jgh3.12697. eCollection 2022 Jan.
2
Omphalomesenteric Duct Anomalies in Children: A Multimodality Overview.小儿脐肠系膜管异常:多模态综述。
Radiographics. 2021 Nov-Dec;41(7):2090-2110. doi: 10.1148/rg.2021210048.
3
Meckel's Diverticulum Imaging.梅克尔憩室成像
Management of gastrointestinal bleed in the intensive care setting, an updated literature review.
重症监护环境下胃肠道出血的管理:最新文献综述
World J Crit Care Med. 2025 Mar 9;14(1):101639. doi: 10.5492/wjccm.v14.i1.101639.
4
Perforation of Meckel's diverticulum by an unusual foreign body: A case report and a review of literature.梅克尔憩室被一种罕见异物穿孔:一例病例报告及文献复习
Clin Case Rep. 2024 Jul 29;12(8):e9183. doi: 10.1002/ccr3.9183. eCollection 2024 Aug.
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[Developmental disorders of the gastrointestinal tract].[胃肠道发育障碍]
Radiologie (Heidelb). 2024 May;64(5):392-399. doi: 10.1007/s00117-024-01302-3. Epub 2024 Apr 10.
6
Congenital lung malformations.先天性肺畸形。
Nat Rev Dis Primers. 2023 Nov 2;9(1):60. doi: 10.1038/s41572-023-00470-1.
J Nucl Med Technol. 2020 Sep;48(3):210-213. doi: 10.2967/jnmt.120.251918.
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Update: Image Gently and Nuclear Medicine at 10 Years.更新:“温柔显影”与核医学十年回顾
J Nucl Med. 2019 Apr;60(4):7N-9N.
5
2016 Update of the North American Consensus Guidelines for Pediatric Administered Radiopharmaceutical Activities.《北美儿科放射性药物给药活动共识指南2016年更新版》
J Nucl Med. 2016 Dec;57(12):15N-18N.
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Diagnosis of Bleeding Meckel's Diverticulum in Adults.成人梅克尔憩室出血的诊断
PLoS One. 2016 Sep 14;11(9):e0162615. doi: 10.1371/journal.pone.0162615. eCollection 2016.
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Many faces of Meckel's diverticulum and its complications.梅克尔憩室及其并发症的多面性。
Jpn J Radiol. 2016 May;34(5):313-20. doi: 10.1007/s11604-016-0530-x. Epub 2016 Mar 1.
8
The value of repeat scintigraphy in patients with a high clinical suspicion for Meckel diverticulum after a negative or equivocal first Meckel scan.首次梅克尔扫描结果为阴性或不确定后,重复闪烁扫描在临床高度怀疑梅克尔憩室患者中的价值。
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