O'Dougherty M, Wright F S, Cox S, Walson P
Arch Neurol. 1987 Aug;44(8):863-7. doi: 10.1001/archneur.1987.00520200065021.
Neuropsychological function was assessed before and after carbamazepine monotherapy in children with newly diagnosed complex partial epilepsy. Simultaneous video-electroencephalographic monitoring examined the influence of subclinical abnormal electrical discharges on performance. Total and unbound plasma carbamazepine concentrations were examined in relation to changes in performance at low (carbamazepine level, less than or equal to 32 mumol/L [less than or equal to 7.5 mg/L]) and moderate (carbamazepine level, greater than 34 mumol/L [greater than 8.0 mg/L]) drug levels. The data suggest a mild beneficial effect of carbamazepine on speeded eye-hand coordination and, at low drug levels, more rapid processing of items in memory. Efficiency of learning new information and memory-scanning rate displayed a concentration-dependent relationship with carbamazepine level, with poor performance significantly associated with higher carbamazepine plasma concentrations. Carbamazepine free levels were equivalent to total levels in predicting cognitive side effects.
对新诊断的复杂部分性癫痫患儿进行卡马西平单药治疗前后的神经心理功能评估。同步视频脑电图监测检查亚临床异常放电对表现的影响。针对低（卡马西平水平，小于或等于32 μmol/L[小于或等于7.5 mg/L]）和中等（卡马西平水平，大于34 μmol/L[大于8.0 mg/L]）药物水平，检测了血浆总卡马西平和游离卡马西平浓度与表现变化的关系。数据表明，卡马西平对快速眼手协调有轻度有益作用，且在低药物水平时，对记忆中项目的处理更快。学习新信息的效率和记忆扫描率与卡马西平水平呈浓度依赖性关系，表现不佳与较高的卡马西平血浆浓度显著相关。在预测认知副作用方面，游离卡马西平水平与总水平相当。
