Ryan S W, Forsythe I, Hartley R, Haworth M, Bowmer C J
Department of Paediatrics and Child Health, General Infirmary, Belmont Grove, Leeds.
Arch Dis Child. 1990 Sep;65(9):930-5. doi: 10.1136/adc.65.9.930.
Thirty three children with poorly controlled epilepsy, and six new patients, were treated with slow release carbamazepine. Twelve of the former had a reduction in the number of seizures of more than half, and 10 had fewer side effects. Three of the new patients stopped having seizures. Variations in plasma concentrations between doses was significantly less when patients took the slow release preparation (22%) compared with the standard preparation (41%). Slow release carbamazepine may improve the conditions of children whose seizures are poorly controlled.
33名癫痫控制不佳的儿童以及6名新患者接受了缓释卡马西平治疗。前者中有12名癫痫发作次数减少超过一半，10名副作用减少。3名新患者停止发作。与标准制剂（41%）相比，患者服用缓释制剂时，剂量间的血浆浓度变化显著更小（22%）。缓释卡马西平可能改善癫痫控制不佳儿童的状况。
