Swartzman Isaac, Gu Juan J, Toner Zachary, Grover Raminder, Suresh Lakshmanan, Ullman Lori E
Dermatology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, USA.
Laboratory Medicine, KSL Biomedical, Inc, Williamsville, USA.
Cureus. 2022 Sep 29;14(9):e29752. doi: 10.7759/cureus.29752. eCollection 2022 Sep.
Coronavirus disease 2019 (COVID-19) infection has been linked to numerous autoimmune manifestations. Neither the mechanism nor the etiology of this association has been fully explored or elucidated. Prior studies have detected myositis in patients with proven COVID-19 infection, suggesting a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the development of myositis. Studies have reported elevated levels of autoimmune antibodies, including myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs), in patients with COVID-19 infection, however the prevalence is not well documented. Our objective was to assess the prevalence of MSAs and MAAs in COVID-19 patients compared with unaffected subjects. Serum samples from 74 unvaccinated, polymerase chain reaction (PCR)-positive COVID-19 infected patients were compared with serum samples from 41 healthy, unaffected individuals. All serum samples were tested for MSA and MAA reactivity. Within the COVID-19-positive group, six (8.1%) patients exhibited MSA/MAA positivity, compared with only one (2.4%) individual from the control group. Although a higher prevalence of MSA/MAA positivity was observed within the COVID-19 infected group, the difference did not reach statistical significance (p=0.223). The autoantibodies detected in this study have a unique association with dermatomyositis and other inflammatory myopathies, and may play a role in COVID-19-associated myopathy. This article was previously presented as an abstract at Jacobs School of Medicine and Biomedical Sciences Research Day on June 3rd, 2022.
2019冠状病毒病（COVID-19）感染与多种自身免疫表现有关。这种关联的机制和病因均未得到充分探索或阐明。先前的研究在确诊为COVID-19感染的患者中检测到了肌炎，提示严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染与肌炎的发生之间存在关联。研究报告称，COVID-19感染患者体内自身免疫抗体水平升高，包括肌炎特异性自身抗体（MSA）和肌炎相关自身抗体（MAA），然而其患病率尚无充分记录。我们的目的是评估COVID-19患者与未受影响的受试者相比，MSA和MAA的患病率。将74名未接种疫苗、聚合酶链反应（PCR）检测呈阳性的COVID-19感染患者的血清样本与41名健康未受影响个体的血清样本进行比较。所有血清样本均检测了MSA和MAA反应性。在COVID-19阳性组中，有6名（8.1%）患者MSA/MAA呈阳性，而对照组中只有1名（2.4%）个体呈阳性。尽管在COVID-19感染组中观察到MSA/MAA阳性的患病率较高，但差异未达到统计学意义（p=0.223）。本研究中检测到的自身抗体与皮肌炎和其他炎性肌病有独特关联，可能在COVID-19相关肌病中起作用。本文曾于2022年6月3日在雅各布斯医学院和生物医学科学研究日作为摘要发表。
