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女性膀胱癌患者局部肿瘤切除和根治性膀胱切除术后的死亡原因:一项基于当代美国人群的分析。

Causes of death in female patients with bladder cancer after local tumor excision and radical cystectomy: a contemporary, US population-based analysis.

机构信息

Robot Minimally Invasive Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 610072, China.

出版信息

Eur J Med Res. 2022 Nov 4;27(1):230. doi: 10.1186/s40001-022-00873-y.


DOI:10.1186/s40001-022-00873-y
PMID:36329537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9635151/
Abstract

Surgery is one of the most important treatments for bladder cancer, including local tumor excision and radical cystectomy. At present, studies on the causes of death for contemporary survivors, especially women, who have received different surgical treatments are limited. Therefore, the study used a population-based cohort study in the United States from 2000 to 2017 to analyze causes of death for women who underwent local tumor excision or radical cystectomy stratified by demographics and tumor stage. standardized mortality ratios (SMRs) were calculated based on general population data. In total, 24,040 female patients who underwent surgical treatments were assessed. Of those 20,780 patients undergoing local tumor excision, 36.6% died of bladder cancer, while 63.4% died of other causes. The risk of death from all causes increased in comparation with the general population (SMR 1.85; 95% CI 1.82-1.87), and the most common non-tumor cause of death was from heart diseases (16.2%; SMR 1.13; 95% CI 1.09-1.16). Among women who receive radical cystectomy, 82.3% of deaths occurred within 5 years after surgery. 66.9% deaths resulted from bladder cancer, and the risk of death from all causes significantly higher than that in the general people (SMR 4.67; 95% CI 4.51-4.84). Moreover, the risk of death from non- bladder cancer causes also increased, in particular, such as septicemia (SMR 3.09; 95% CI 2.13-4.34). Causes of death during bladder cancer survivorship after surgery vary by patient and tumor characteristics, and these data provide information regarding primary care for women during postoperative cancer survivorship.

摘要

手术是膀胱癌最重要的治疗方法之一,包括局部肿瘤切除和根治性膀胱切除术。目前,对于接受不同手术治疗的当代幸存者(尤其是女性)的死亡原因的研究有限。因此,本研究使用了美国 2000 年至 2017 年的一项基于人群的队列研究,分析了接受局部肿瘤切除或根治性膀胱切除术的女性患者按人口统计学和肿瘤分期分层的死亡原因。根据一般人群数据计算标准化死亡率(SMR)。共有 24040 名接受手术治疗的女性患者接受了评估。在接受局部肿瘤切除的 20780 名患者中,36.6%死于膀胱癌,63.4%死于其他原因。与一般人群相比,全因死亡风险增加(SMR 1.85;95%CI 1.82-1.87),最常见的非肿瘤死因是心脏病(16.2%;SMR 1.13;95%CI 1.09-1.16)。接受根治性膀胱切除术的女性中,82.3%的死亡发生在手术后 5 年内。66.9%的死亡归因于膀胱癌,全因死亡风险明显高于一般人群(SMR 4.67;95%CI 4.51-4.84)。此外,非膀胱癌原因的死亡风险也增加,特别是败血症(SMR 3.09;95%CI 2.13-4.34)。手术后膀胱癌生存期间的死亡原因因患者和肿瘤特征而异,这些数据为女性术后癌症生存期间的初级保健提供了信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d00b/9635151/bda5f9a448dd/40001_2022_873_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d00b/9635151/bda5f9a448dd/40001_2022_873_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d00b/9635151/bda5f9a448dd/40001_2022_873_Fig1_HTML.jpg

相似文献

[1]
Causes of death in female patients with bladder cancer after local tumor excision and radical cystectomy: a contemporary, US population-based analysis.

Eur J Med Res. 2022-11-4

[2]
Cause of death during prostate cancer survivorship: A contemporary, US population-based analysis.

Cancer. 2021-8-15

[3]
A study of the morbidity, mortality and long-term survival following radical cystectomy and radical radiotherapy in the treatment of invasive bladder cancer in Yorkshire.

Eur Urol. 2003-3

[4]
[Results of radical cystectomy for management of invasive bladder cancer with special reference to prognostic factors and quality of life depending on the type of urinary diversion].

Ann Acad Med Stetin. 2000

[5]
Extended versus standard lymph node dissection for urothelial carcinoma of the bladder in patients undergoing radical cystectomy.

Cochrane Database Syst Rev. 2019-5-14

[6]
Bladder sparing surgery in high-grade bladder cancer.

Exp Oncol. 2019-6

[7]
Comparative effectiveness of robot-assisted vs. open radical cystectomy.

Urol Oncol. 2018-3

[8]
Comparing Survival Outcomes and Costs Associated With Radical Cystectomy and Trimodal Therapy for Older Adults With Muscle-Invasive Bladder Cancer.

JAMA Surg. 2018-10-1

[9]
Randomized Trial Comparing Open Radical Cystectomy and Robot-assisted Laparoscopic Radical Cystectomy: Oncologic Outcomes.

Eur Urol. 2018-5-18

[10]
Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial.

Lancet. 2018-6-23

本文引用的文献

[1]
A Comparative Study of the Triglycerides/HDL Ratio and Pseudocholinesterase Levels in Patients with Bladder Cancer.

Diagnostics (Basel). 2022-2-7

[2]
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Hematol Oncol Clin North Am. 2021-6

[3]
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JAMA. 2020-11-17

[4]
Laparoscopic radical cystectomy with extracorporeal urinary diversion: an Italian single-center experience with 10-year outcomes.

Minerva Urol Nefrol. 2020-10

[5]
Management of Muscle-invasive Bladder Cancer in the 2020s: Challenges and Perspectives.

Eur Urol Focus. 2020-7-15

[6]
Long-term Oncological Outcomes from an Early Phase Randomised Controlled Three-arm Trial of Open, Robotic, and Laparoscopic Radical Cystectomy (CORAL).

Eur Urol. 2020-1

[7]
The global burden of urinary bladder cancer: an update.

World J Urol. 2020-8

[8]
Systematic Literature Review and Meta-Analysis of Response to First-Line Therapies for Advanced/Metastatic Urothelial Cancer Patients Who Are Cisplatin Ineligible.

Am J Clin Oncol. 2019-10

[9]
Causes of death in long-term bladder cancer survivors: A population-based study.

Asia Pac J Clin Oncol. 2019-10

[10]
Cancer statistics, 2019.

CA Cancer J Clin. 2019-1-8

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