Lasica Ratko, Spasic Jelena, Djukanovic Lazar, Trifunovic-Zamaklar Danijela, Orlic Dejan, Nedeljkovic-Arsenovic Olga, Asanin Milika
Department of Cardiology, Emergency Center, University Clinical Center of Serbia, Belgrade, Serbia.
Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
Front Cardiovasc Med. 2022 Oct 18;9:991886. doi: 10.3389/fcvm.2022.991886. eCollection 2022.
Considering the pandemic of both cardiovascular diseases and oncological diseases, there is an increasing need for the use of chemotherapy, which through various pathophysiological mechanisms leads to damage to heart function. Cardio toxicity of chemotherapy drugs can manifest itself in a variety of clinical manifestations, which is why establishing a valid diagnosis is a real mystery for clinicians. Acute systolic heart failure (AHF) due to the use of 5-fluorouracil (5-FU) is a rare occurrence if it is not associated with myocardial infarction, myocarditis or Takotsubo cardiomyopathy. Therefore, we decided to present a case of an 52-year-old male who was diagnosed with stage IV RAS wild-type adenocarcinoma of the rectum and in whom the direct toxic effect 5-FU is the main reason for the appearance of toxic cardiomyopathy.
考虑到心血管疾病和肿瘤疾病的大流行，对化疗的需求日益增加，而化疗通过各种病理生理机制会导致心脏功能损害。化疗药物的心脏毒性可表现为多种临床表现，这就是为什么对临床医生来说，建立有效的诊断是一个真正的难题。如果不伴有心肌梗死、心肌炎或应激性心肌病，使用5-氟尿嘧啶（5-FU）导致的急性收缩性心力衰竭（AHF）是一种罕见情况。因此，我们决定介绍一例52岁男性患者，他被诊断为IV期RAS野生型直肠腺癌，5-FU的直接毒性作用是其毒性心肌病出现的主要原因。
