Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman.
ScientificWorldJournal. 2022 Oct 25;2022:4102960. doi: 10.1155/2022/4102960. eCollection 2022.
Pits of dates ( L.) have numerous nutritional benefits that could have wide-ranging applications. This study aimed to examine the effects of administering three extracts from powdered date pits on some basic physiological parameters, plasma constituents, reproductive hormones, and testicular histology in CD1 male mice. Three groups received doses of 100 mg/kg/day of lyophilized extract, a nonpolar fraction, and a polar fraction of date pits by oral gavage for 28 consecutive days. For the control, one group was administered a 1 mL/kg concentration of distilled water. The three different extracts significantly increased the plasma testosterone level but showed no significant effect on estradiol or luteinizing hormone levels, except for estradiol reduction in the polar extract group. The measured physiological or biochemical parameters or testicular histology also demonstrated no significant differences between the control mice and those mice treated with the three extracts, except for reductions in plasma urea in all extracts and in total protein in the nonpolar extract. Therefore, date pit extracts may potentially be used as a safe and effective dietary supplement. However, further investigation is needed.
枣核（L.）具有许多营养价值，可能具有广泛的应用。本研究旨在研究三种从枣核粉中提取的提取物对 CD1 雄性小鼠的一些基本生理参数、血浆成分、生殖激素和睾丸组织学的影响。三组小鼠分别通过口服灌胃接受 100mg/kg/天的冻干提取物、非极性部分和极性部分的剂量，连续 28 天。对照组给予 1ml/kg 浓度的蒸馏水。三种不同的提取物显著增加了血浆睾酮水平，但对雌二醇或促黄体生成素水平没有显著影响，除了极性提取物组的雌二醇降低。测量的生理或生化参数或睾丸组织学也没有显示出对照组和三种提取物处理组之间有显著差异，除了所有提取物中血浆尿素减少和非极性提取物中总蛋白减少。因此，枣核提取物可能可作为一种安全有效的膳食补充剂。然而，还需要进一步的研究。
