Adebayo Francis O, Ameh Nkeiruka, Adesiyun Adebiyi G, Ekele Bissallah A, Wada Ibrahim
Invitro Fertilization Unit, Nisa Fertility and Genetic Center, Abuja, Nigeria.
Department of Obstetrics and Gynecology, Ahmadu Bello University, Zaria, Nigeria.
Int J Gynaecol Obstet. 2023 Apr;161(1):283-288. doi: 10.1002/ijgo.14545. Epub 2022 Nov 15.
To determine the effect of female age on pregnancy outcome after in vitro fertilization/embryo transfer (IVF-ET).
A prospective study was conducted involving 266 women who had IVF-ET at Nisa Fertility and Genetic Center, Abuja, Nigeria. All eligible consenting women were recruited to the study. The main outcome measure was clinical pregnancy. Data were analyzed using IBM SPSS Statistics version 25. P < 0.05 at 95% confidence intervals was taken as significant.
A total of 266 patients were recruited and included in the study; 104 pregnancies were recorded, giving an overall pregnancy rate of 39.1%. The age range of the patient was 26-43 years (mean age 33.9 ± 2.41 years) while the mean number of embryo transfers per patient was 2.2. The clinical pregnancy rate for women aged below 30 years was 69.4% while the pregnancy rate for patients aged 30-34 years, 35-39 years, and 40-43 years was 52.6%, 24.7%, and 9.4%, respectively (P < 0.0001).
The study found that the success rate of IVF-ET decreases significantly in women aged over 34 years. Women should be counseled about the age-related risk of infertility and referred to a fertility center as early as possible.
确定女性年龄对体外受精/胚胎移植（IVF-ET）后妊娠结局的影响。
在尼日利亚阿布贾的尼萨生育与遗传中心对266例行IVF-ET的女性进行了一项前瞻性研究。所有符合条件并同意参与的女性均被纳入研究。主要结局指标为临床妊娠。使用IBM SPSS Statistics 25版对数据进行分析。95%置信区间下P < 0.05被视为具有统计学意义。
共招募并纳入266例患者；记录到104例妊娠，总体妊娠率为39.1%。患者年龄范围为26 - 43岁（平均年龄33.9 ± 2.41岁），每位患者平均胚胎移植次数为2.2次。30岁以下女性的临床妊娠率为69.4%，而30 - 34岁、35 - 39岁和40 - 43岁患者的妊娠率分别为52.6%、24.7%和9.4%（P < 0.0001）。
该研究发现，34岁以上女性IVF-ET的成功率显著降低。应向女性咨询与年龄相关的不孕风险，并尽早转诊至生育中心。
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