Center for Radiological Research, Columbia University Irving Medical Center, New York, NY.
Photochem Photobiol. 2023 May-Jun;99(3):1047-1050. doi: 10.1111/php.13739. Epub 2022 Nov 21.
Far UVC light (UVC wavelengths below 235 nm) is a comparatively new modality with significant potential to safely and very efficiently inactivate airborne pathogens in occupied indoor locations. There are now significant accumulations of evidence both in terms of the safety of far-UVC for direct exposure of occupied indoor locations, and in terms of its efficacy to markedly reduce the levels of active airborne pathogens This article reviews both the safety of far-UVC, which has a clear mechanistic underpinning, and its efficacy, both in the laboratory and in full-sized rooms. Highlighted is the paper by Ma et al. in this issue of Photochemistry and Photobiology which addresses the efficacy of far-UVC light (in this case at 222 nm) against a broad spectrum of common pathogens including SARS-CoV-2 and influenza viruses. From their data, and based on our understanding of the largely random nature of UVC-induced damage within the genome, far UVC would be expected to be effective against the next pandemic virus, if and when it emerges.
远紫外线 C 光（波长 235nm 以下的紫外线 C）是一种相对较新的模式，具有很大的潜力，可以安全且非常有效地消灭室内有人居住场所中的空气传播病原体。现在已经积累了大量的证据，证明远紫外线 C 对有人居住的室内场所进行直接照射是安全的，并且证明其对明显降低活性空气传播病原体的水平是有效的。本文综述了远紫外线 C 的安全性，这是一种有明确机制支持的安全性，以及它的功效，包括在实验室和全尺寸房间中的功效。这篇文章强调了 Ma 等人在本期《光化学与光生物学》中发表的论文，该论文探讨了远紫外线 C 光（在这种情况下为 222nm）对包括 SARS-CoV-2 和流感病毒在内的多种常见病原体的功效。根据他们的数据，并且基于我们对紫外线 C 诱导的基因组内损伤在很大程度上是随机性质的理解，远紫外线 C 有望对下一次大流行病毒有效，假如它出现的话。
