Center for Radiological Research, Columbia University Irving Medical Center, New York, NY 10032, USA.
School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK.
Viruses. 2022 Mar 25;14(4):684. doi: 10.3390/v14040684.
Recent research using UV radiation with wavelengths in the 200-235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose-response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose-response relation, and the estimated susceptibility constant at low doses-the relevant parameter for realistic low dose rate exposures-was 12.4 ± 0.4 cm/mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens.
最近的研究使用波长在 200-235nm 范围内的紫外线辐射，通常称为远紫外线 C （far-UVC），表明与这些波长相关的最小健康危害将允许在有人居住的室内空间直接使用远紫外线 C 辐射进行连续消毒。早期的实验研究根据将指数剂量-反应曲线拟合到数据上来估计暴露于 222nm 辐射的空气传播人类冠状病毒 OC43 的易感性。本研究将结果扩展到更宽范围的 222nm 远紫外线 C 辐射剂量，并使用耦合辐射传输和计算流体动力学的计算模型来提高剂量估计。新结果表明，在我们的暴露系统中，人类冠状病毒 OC43 的失活可以更好地用双指数剂量-反应关系来描述，而在低剂量下（与实际低剂量率暴露相关的参数）的估计敏感性常数为 12.4±0.4cm/mJ，描述了 99.7%±0.05%的病毒群体的行为。这个新的估计值是基于单指数剂量反应的早期敏感性常数估计值的两倍多。这些新结果进一步证明了远紫外线 C 对空气传播病原体的灭活效果。
