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Berberine regulates UCP1 expression by reshaping the conformation of quadruplex formed by the element of the gene promoter.

作者信息

Wang Qiuhui, Xu Xingke, Jiang Xiaoqing, Yin Fei

机构信息

Chongqing Key Laboratory of Medicinal Chemistry & Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China.

College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.

出版信息

Acta Biochim Biophys Sin (Shanghai). 2022 Nov 25;54(11):1757-1760. doi: 10.3724/abbs.2022155.

DOI:10.3724/abbs.2022155
PMID:36331298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9828300/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e85f/9828300/4c7e02c944a7/ABBS-2022-118-t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e85f/9828300/fdbb51f1f472/ABBS-2022-118-t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e85f/9828300/4c7e02c944a7/ABBS-2022-118-t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e85f/9828300/fdbb51f1f472/ABBS-2022-118-t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e85f/9828300/4c7e02c944a7/ABBS-2022-118-t2.jpg

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本文引用的文献

1
The effect of Berberine on weight loss in order to prevent obesity: A systematic review.小檗碱对减肥预防肥胖的作用：系统评价。
Biomed Pharmacother. 2020 Jul;127:110137. doi: 10.1016/j.biopha.2020.110137. Epub 2020 Apr 27.
2
Physical training, UCP1 expression, mitochondrial density, and coupling in adipose tissue from women with obesity.肥胖女性脂肪组织的体能训练、UCP1 表达、线粒体密度和偶联
Scand J Med Sci Sports. 2019 Nov;29(11):1699-1706. doi: 10.1111/sms.13514. Epub 2019 Jul 22.
3
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
UCP1 和棕色脂肪组织中线粒体代谢的可逆琥珀酰化调节。
Mol Cell. 2019 May 16;74(4):844-857.e7. doi: 10.1016/j.molcel.2019.03.021. Epub 2019 Apr 15.
4
New Advances in Adaptive Thermogenesis: UCP1 and Beyond.适应性生热的新进展：解耦蛋白 1 及其他。
Cell Metab. 2019 Jan 8;29(1):27-37. doi: 10.1016/j.cmet.2018.11.002. Epub 2018 Nov 29.
5
Identification of a G-quadruplex forming sequence in the promoter of UCP1.鉴定 UCP1 启动子中的 G-四链体形成序列。
Acta Biochim Biophys Sin (Shanghai). 2018 Jul 1;50(7):718-722. doi: 10.1093/abbs/gmy059.
6
Berberine activates thermogenesis in white and brown adipose tissue.小檗碱激活白色和棕色脂肪组织的产热作用。
Nat Commun. 2014 Nov 25;5:5493. doi: 10.1038/ncomms6493.
7
The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.解偶联蛋白1（UCP1）在肥胖症和2型糖尿病发生发展中的作用。
Arq Bras Endocrinol Metabol. 2012 Jun;56(4):215-25. doi: 10.1590/s0004-27302012000400001.
8
Quadruplex DNA: sequence, topology and structure.四链体DNA：序列、拓扑结构与结构
Nucleic Acids Res. 2006;34(19):5402-15. doi: 10.1093/nar/gkl655. Epub 2006 Sep 29.
9
The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research.人类解偶联蛋白-1基因（UCP1）：肥胖研究的现状与展望
Obes Rev. 2000 Oct;1(2):61-72. doi: 10.1046/j.1467-789x.2000.00009.x.
10
Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA.四重链DNA的钾离子饱和型、2:1型和中间型（1:1型）结构。
Nucleic Acids Res. 2000 May 1;28(9):1969-77. doi: 10.1093/nar/28.9.1969.