Brondani Letícia de Almeida, Assmann Taís Silveira, Duarte Guilherme Coutinho Kullmann, Gross Jorge Luiz, Canani Luís Henrique, Crispim Daisy
Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, RS, Brazil.
Arq Bras Endocrinol Metabol. 2012 Jun;56(4):215-25. doi: 10.1590/s0004-27302012000400001.
It is well established that genetic factors play an important role in the development of both type 2 diabetes mellitus (DM2) and obesity, and that genetically susceptible subjects can develop these metabolic diseases after being exposed to environmental risk factors. Therefore, great efforts have been made to identify genes associated with DM2 and/or obesity. Uncoupling protein 1 (UCP1) is mainly expressed in brown adipose tissue, and acts in thermogenesis, regulation of energy expenditure, and protection against oxidative stress. All these mechanisms are associated with the pathogenesis of DM2 and obesity. Hence, UCP1 is a candidate gene for the development of these disorders. Indeed, several studies have reported that polymorphisms -3826A/G, -1766A/G and -112A/C in the promoter region, Ala64Thr in exon 2 and Met299Leu in exon 5 of UCP1 gene are possibly associated with obesity and/or DM2. However, results are still controversial in different populations. Thus, the aim of this study was to review the role of UCP1 in the development of these metabolic diseases.
众所周知，遗传因素在2型糖尿病（DM2）和肥胖症的发生发展中起着重要作用，而且遗传易感性个体在暴露于环境风险因素后可能会患上这些代谢性疾病。因此，人们已付出巨大努力来确定与DM2和/或肥胖症相关的基因。解偶联蛋白1（UCP1）主要在棕色脂肪组织中表达，并在产热、能量消耗调节及抗氧化应激中发挥作用。所有这些机制都与DM2和肥胖症的发病机制相关。因此，UCP1是这些疾病发生发展的候选基因。事实上，多项研究报告称，UCP1基因启动子区域的-3826A/G、-1766A/G和-112A/C多态性、外显子2中的Ala64Thr以及外显子5中的Met299Leu可能与肥胖症和/或DM2相关。然而，不同人群中的研究结果仍存在争议。因此，本研究的目的是综述UCP1在这些代谢性疾病发生发展中的作用。
