Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Scand J Med Sci Sports. 2023 Mar;33(3):307-318. doi: 10.1111/sms.14261. Epub 2022 Nov 16.
Physical activity benefits cardiometabolic health, but little is known about its detailed links with serum lipoproteins, amino acids, and glucose metabolism at young age. We therefore studied the association of physical activity with a comprehensive metabolic profile measured repeatedly in adolescence.
The cohort is derived from the longitudinal Special Turku Coronary Risk Factor Intervention Project. At ages 13, 15, 17, and 19 years, data on physical activity were collected by a questionnaire, and circulating metabolic measures were quantified by nuclear magnetic resonance metabolomics from repeatedly assessed serum samples (age 13: n = 503, 15: n = 472, 17: n = 466, and 19: n = 361).
Leisure-time physical activity (LTPA;MET h/wk) was directly associated with concentrations of polyunsaturated fatty acids, and inversely with the ratio of monounsaturated fatty acids to total fatty acids (-0.006SD; [-0.008, -0.003]; p < 0.0001). LTPA was inversely associated with very-low-density lipoprotein (VLDL) particle concentration (-0.003SD; [-0.005, -0.001]; p = 0.002) and VLDL particle size (-0.005SD; [-0.007, -0.003]; p < 0.0001). LTPA showed direct association with the particle concentration and size of high-density lipoprotein (HDL), and HDL cholesterol concentration (0.004SD; [0.002, 0.006]; p < 0.0001). Inverse associations of LTPA with triglyceride and total lipid concentrations in large to small sized VLDL subclasses were found. Weaker associations were seen for other metabolic measures including inverse associations with concentrations of lactate, isoleucine, glycoprotein acetylation, and a direct association with creatinine concentration. The results remained after adjusting for body mass index and proportions of energy intakes from macronutrients.
Physical activity during adolescence is beneficially associated with the metabolic profile including novel markers. The results support recommendations on physical activity during adolescence to promote health and possibly reduce future disease risks.
身体活动有益于心脏代谢健康，但我们对其与青少年血清脂蛋白、氨基酸和葡萄糖代谢的详细关系知之甚少。因此，我们研究了身体活动与青少年时期反复测量的综合代谢特征之间的关联。
该队列源自纵向特殊图尔库冠心病风险因素干预项目。在 13、15、17 和 19 岁时，通过问卷调查收集身体活动数据，并通过核磁共振代谢组学从反复评估的血清样本中量化循环代谢指标（年龄 13：n=503，15：n=472，17：n=466，19：n=361）。
休闲时间体力活动（LTPA；MET h/wk）与多不饱和脂肪酸的浓度呈正相关，与单不饱和脂肪酸与总脂肪酸的比值呈负相关（-0.006SD；[-0.008，-0.003]；p<0.0001）。LTPA 与极低密度脂蛋白（VLDL）颗粒浓度（-0.003SD；[-0.005，-0.001]；p=0.002）和 VLDL 颗粒大小（-0.005SD；[-0.007，-0.003]；p<0.0001）呈负相关。LTPA 与高密度脂蛋白（HDL）的颗粒浓度和大小以及 HDL 胆固醇浓度呈正相关（0.004SD；[0.002，0.006]；p<0.0001）。还发现 LTPA 与大到小的 VLDL 亚类中的甘油三酯和总脂质浓度呈负相关。对于其他代谢指标，如乳酸、异亮氨酸、糖蛋白乙酰化浓度的负相关，以及肌酐浓度的直接相关，其关联较弱。在调整了体重指数和宏量营养素能量摄入比例后，结果仍然成立。
青少年时期的身体活动与包括新型标志物在内的代谢特征呈有益相关。这些结果支持了在青少年时期进行身体活动的建议，以促进健康并可能降低未来的疾病风险。
