Jelenkovic Aline, Bogl Leonie H, Rose Richard J, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kaprio Jaakko, Silventoinen Karri
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa 48940, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao 48011, Spain; Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki 00014, Finland.
Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki 00014, Finland.
Atherosclerosis. 2014 Apr;233(2):394-402. doi: 10.1016/j.atherosclerosis.2013.12.053. Epub 2014 Jan 21.
Little is known about the associations of serum fatty acids with lipoprotein profile and the underlying genetic and environmental etiology of these relationships. We aimed to analyze the phenotypic association of serum n-6 and n-3 polyunsaturated (PUFAs), monounsaturated (MUFAs) and saturated (SFAs) fatty acids (relative proportion to total fatty acids) with lipids and lipoproteins, and to quantify common genetic and environmental factors determining their covariation.
Two cohorts of healthy Finnish twins were assessed in young adulthood. Data were available for 1269 individual twins including 561 complete pairs. Serum metabolites were measured by nuclear magnetic resonance spectroscopy. Bivariate quantitative genetic models were used to decompose the phenotypic covariance between the pairs of traits into genetic and environmental components.
Among the strongest correlations observed, serum total n-6 PUFAs and linoleic acid were inversely (max. r=-0.65) and MUFAs positively (max. r=0.63) correlated with triglycerides and very low-density lipoprotein (VLDL) particle concentration, particularly with large VLDL (for n-6 PUFAs) and medium VLDL (for MUFAs). Genetic factors significantly contributed to their covariance with bivariate heritability estimates ranging from 44% to 56% for n-6 PUFAs and 58% to 66% for MUFAs. Genetic correlations with lipid traits were moderate to high (max. rA=-0.59 and 0.70 for n-6 PUFAs and MUFAs, respectively). Statistically significant, but substantially weaker phenotypic correlations of total n-3 PUFAs, docosahexaenoic acid (DHA) and SFAs with lipoprotein profile were not decomposed into their genetic and environmental components.
Shared genetic factors are important in explaining why higher concentrations of serum n-6 PUFAs and lower concentrations of serum MUFAs strongly associate with lower triglyceride and VLDL particle concentrations.
关于血清脂肪酸与脂蛋白谱之间的关联以及这些关系背后的遗传和环境病因，我们所知甚少。我们旨在分析血清n-6和n-3多不饱和脂肪酸（PUFAs）、单不饱和脂肪酸（MUFAs）和饱和脂肪酸（SFAs）（占总脂肪酸的相对比例）与脂质和脂蛋白的表型关联，并量化决定它们协变的常见遗传和环境因素。
对两组芬兰健康双胞胎进行了青年期评估。有1269名个体双胞胎的数据，包括561对完整双胞胎。血清代谢物通过核磁共振光谱法测量。使用双变量定量遗传模型将性状对之间的表型协方差分解为遗传和环境成分。
在观察到的最强相关性中，血清总n-6 PUFAs和亚油酸与甘油三酯和极低密度脂蛋白（VLDL）颗粒浓度呈负相关（最大r=-0.65），MUFAs与甘油三酯和VLDL颗粒浓度呈正相关（最大r=0.63），特别是与大颗粒VLDL（对于n-6 PUFAs）和中颗粒VLDL（对于MUFAs）。遗传因素对它们的协方差有显著贡献，n-6 PUFAs的双变量遗传力估计范围为44%至56%，MUFAs为58%至66%。与脂质性状的遗传相关性为中度至高度（n-6 PUFAs和MUFAs的最大rA分别为-0.59和0.70）。总n-3 PUFAs、二十二碳六烯酸（DHA）和SFAs与脂蛋白谱的统计学显著但明显较弱的表型相关性未分解为遗传和环境成分。
共享的遗传因素对于解释为什么血清n-6 PUFAs浓度较高和血清MUFAs浓度较低与较低的甘油三酯和VLDL颗粒浓度密切相关很重要。
