肠道转运时间对柳氮磺胺吡啶（水杨酸偶氮磺胺吡啶）偶氮还原的影响。
Influence of intestinal transit time on azo-reduction of salicylazosulphapyridine (Salazopyrin).
作者信息
van Hees P A, Tuinte J H, van Rossum J M, van Tongeren J H
出版信息
Gut. 1979 Apr;20(4):300-4. doi: 10.1136/gut.20.4.300.
Abstract
During a normal and an accelerated intestinal transit, in seven healthy volunteers, the recoveries of salicylazosulphapyridine (SASP) and its split products sulphapyridine (SP) and 5-aminosalicylic acid (5-ASA) were determined in urine and faeces. The azo-reduction of SASP and consequently the recovery of 5-ASA in the faeces was found to be substantially decreased during an accelerated intestinal transit. In addition, in 18 patients with inflammatory disease of the colon during maintenance therapy of SASP it could be demonstrated that the serum SP levels were related to the diarrhoeal state and did not correlate with disease activity. As recent studies have reported that 5-ASA is possibly the active therapeutic moiety of SASP, the ineffectiveness of SASP therapy in patients with active colitis may be ascribed to the reduced azo reduction of SASP as the result of profuse diarrhoea.
摘要
在七名健康志愿者的正常和加速肠道转运过程中，测定了尿和粪便中柳氮磺胺吡啶（SASP）及其分解产物磺胺吡啶（SP）和5-氨基水杨酸（5-ASA）的回收率。发现在加速肠道转运过程中，SASP的偶氮还原以及粪便中5-ASA的回收率显著降低。此外，在18例接受SASP维持治疗的结肠炎症性疾病患者中，可以证明血清SP水平与腹泻状态相关，与疾病活动度无关。由于最近的研究报道5-ASA可能是SASP的活性治疗部分，因此SASP治疗对活动性结肠炎患者无效可能归因于腹泻过多导致SASP的偶氮还原减少。
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