霍奇金病患者外周血中的大颗粒淋巴细胞、Leu 7反应性及自然杀伤细胞功能
Large granular lymphocytes, Leu 7 reactivity and natural killer cell function in peripheral blood of patients with Hodgkin's disease.
作者信息
Berényi E, Surányi P, Pálóczi K, Szegedi G
出版信息
Cancer Immunol Immunother. 1986;21(2):164-6. doi: 10.1007/BF00199866.
The percentage and absolute number of lymphocytes and Leu 7+ cells were significantly lower in HD even in active stages. There was no significant difference in the percentage of LGL between the three groups (control, active HD, inactive HD), however, because of differences in counts of lymphocytes the absolute number of LGL was significantly lower in HD even in the active group than that in healthy controls. The absolute count of LGL and Leu 7+ cells in patients in remission was significantly higher than that in active HD. Natural cytotoxicity against K-562 cells was also significantly lower in active patients in comparison with controls, while the percentage of cytotoxicity was slightly but not significantly higher in patients in remission than that in the active group. A positive correlation was observed between all the three examined parameters both in controls and in patients with active and inactive HD.
即使在活动期，霍奇金病（HD）患者淋巴细胞和Leu 7 +细胞的百分比及绝对数也显著降低。三组（对照组、活动期HD、非活动期HD）之间大颗粒淋巴细胞（LGL）百分比无显著差异，然而，由于淋巴细胞计数不同，即使在活动期HD组，LGL的绝对数也显著低于健康对照组。缓解期患者LGL和Leu 7 +细胞的绝对计数显著高于活动期HD患者。与对照组相比，活动期患者对K - 562细胞的自然细胞毒性也显著降低，而缓解期患者的细胞毒性百分比略高于活动期组，但差异不显著。在对照组以及活动期和非活动期HD患者中，所检测的三个参数之间均观察到正相关。
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