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通过单克隆HNK-1抗体鉴定的人类自然杀伤细胞和杀伤细胞群体的产后扩增。

Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody.

作者信息

Abo T, Cooper M D, Balch C M

出版信息

J Exp Med. 1982 Jan 1;155(1):321-6. doi: 10.1084/jem.155.1.321.

DOI:10.1084/jem.155.1.321
PMID:7054358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186573/
Abstract

Human natural killer (NK) and killer (K) cells were directly enumerated using a monoclonal antibody (HNK-1) and an immunofluorescence assay. The frequency of cells bearing surface HNK-1 antigen was very low in the newborn (less than 1.0%) and increased progressively through childhood and into adult life. This was correlated with an age-related increase in functional NK and K cell activities. Males had a slightly higher proportion of HNK-1+ cells than females. In addition to HNK-1 expression on the surface membrane, a prominent cytoplasmic expression of HNK-1 antigen was found in some but not all surface HNK-1+ cells. The cytoplasmic accumulation of HNK-1 molecules appeared to occur in more mature cells of this lineage.

摘要

利用单克隆抗体（HNK-1）和免疫荧光测定法直接计数人类自然杀伤（NK）细胞和杀伤（K）细胞。新生儿中携带表面HNK-1抗原的细胞频率非常低（低于1.0%），并在儿童期逐渐增加，直至成年。这与NK和K细胞功能随年龄增长而增加相关。男性HNK-1+细胞的比例略高于女性。除了表面膜上的HNK-1表达外，在一些但并非所有表面HNK-1+细胞中发现了HNK-1抗原的显著细胞质表达。HNK-1分子的细胞质积累似乎发生在该谱系中更成熟的细胞中。

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Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody.通过单克隆HNK-1抗体鉴定的人类自然杀伤细胞和杀伤细胞群体的产后扩增。
J Exp Med. 1982 Jan 1;155(1):321-6. doi: 10.1084/jem.155.1.321.
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本文引用的文献

1
Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans.年轻和老年人体内淋巴细胞亚群的自然杀伤及抗体依赖性细胞毒性作用
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A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).一种由单克隆抗体（HNK-1）识别的人自然杀伤细胞和杀伤细胞的分化抗原。
J Immunol. 1981 Sep;127(3):1024-9.
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Natural killing (NK) and antibody-dependent cellular cytotoxicity (ADCC) in specific pathogen-free (SPF) miniature swine and germfree piglets. I. Comparison of NK and ADCC.无特定病原体（SPF）小型猪和无菌仔猪的自然杀伤（NK）及抗体依赖性细胞毒性（ADCC）。I. NK与ADCC的比较
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J Exp Med. 1981 Mar 1;153(3):569-82. doi: 10.1084/jem.153.3.569.
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Natural killer cells.自然杀伤细胞。
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Interferon activation of "pre-spontaneous killer" (pre-SK) cells and alteration in kinetics of lysis of both "pre-SK" and active SK cells.干扰素激活“前自发杀伤”（pre-SK）细胞，并改变“前SK”细胞和活性SK细胞的裂解动力学。
J Immunol. 1980 May;124(5):2157-61.
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Lymphocyte subpopulations in the blood of newborn infants.新生儿血液中的淋巴细胞亚群。
Clin Exp Immunol. 1974 Dec;18(4):469-82.
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Lymphocyte cytotoxicity reactions to leukemia-associated antigens in identical twins.同卵双胞胎对白血病相关抗原的淋巴细胞细胞毒性反应。
Int J Cancer. 1972 May 15;9(3):648-58. doi: 10.1002/ijc.2910090323.
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"Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell.小鼠中的“天然”杀伤细胞。II. 对小鼠莫洛尼白血病细胞具有特异性的细胞毒性细胞。杀伤细胞的特性。
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