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足部结核性骨髓炎的罕见表现。

A rare presentation of tubercular osteomyelitis of the foot.

机构信息

Orthopaedic Department, University of Sassari, Italy.

Department Chemistry and Pharmacy, University of Sassari, Italy.

出版信息

J Infect Dev Ctries. 2022 Oct 31;16(10):1655-1659. doi: 10.3855/jidc.15891.

DOI:10.3855/jidc.15891
PMID:36332222
Abstract

Tuberculosis is a communicable disease that is a major cause of ill health. It is one of the top ten causes of death worldwide and the leading cause of death from a single infectious agent. Its most common clinical presentation is pulmonary involvement. However, approximately 23-30% of tuberculosis patients have extrapulmonary symptoms. A rare (1%) clinical presentation of tuberculosis is foot and ankle infection. This is complicated by the fact that the diagnosis of osteoarticular tuberculosis is difficult. Our case was a 66-year-old multi-pathological pensioner, who, while working in the countryside, had an ankle sprain on the left foot, with a lacerated wound of about 2 cm diameter. The non-endemic area and the negative chest X-ray made the diagnosis extremely complex. However, a multidisciplinary approach with the radiologists and the infectious disease department led to clinical stabilization of the patient. Therefore, awareness and high index of suspicion of the disease is essential and referral to experts should be made if diagnosis is indeterminate despite extensive investigations. The knowledge allows early identification of the disease and prompt therapy in order to avoid long-standing untreated infections which typically cause bone destruction and loss of function. The knowledge is also mandatory for western physicians due to increasing international travel, immigration from less developed countries and increased use of immunosuppressive medications. We believe that this article can bring awareness around osteoarticular tuberculosis and help with improving outcome and eradication of the infection. Level of clinical evidence: 4.

摘要

结核病是一种传染病,是导致健康不良的主要原因之一。它是全球十大死因之一,也是单一传染病病原体导致的主要死因。其最常见的临床表现为肺部受累。然而,约 23-30%的结核病患者有肺外症状。结核病的一种罕见(1%)临床表现为足部和踝关节感染。由于骨关节炎结核的诊断困难,情况更加复杂。我们的病例是一位 66 岁的多系统疾病退休人员,他在农村工作时,左脚踝扭伤,有一个直径约 2 厘米的裂伤伤口。非流行地区和阴性的胸部 X 光片使得诊断极其复杂。然而,放射科医生和传染病科的多学科方法使患者的病情得到了临床稳定。因此,如果尽管进行了广泛的检查但仍无法确定诊断,则必须提高对该疾病的认识和高度怀疑,并转介给专家。该知识有助于早期发现疾病并及时进行治疗,以避免长期未经治疗的感染,这通常会导致骨破坏和功能丧失。由于国际旅行增加、来自欠发达国家的移民增加以及免疫抑制药物的使用增加,西方医生也必须掌握该知识。我们相信,本文可以提高对骨关节炎结核的认识,并有助于改善结果和消除感染。临床证据等级:4 级。

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