Weifang People's Hospital, 261000 Weifang, China.
School of Basic Medicine, Weifang Medical University, 261053 Weifang, China.
Immunobiology. 2022 Nov;227(6):152298. doi: 10.1016/j.imbio.2022.152298. Epub 2022 Oct 28.
PLPPs (Phospholipid phosphatases) are widely expressed in different human tissues, regulate cell signal transduction, and are overexpressed in cancers such as gliomas, pancreatic adenocarcinoma, lung adenocarcinoma, and so on. As a member of the PLPP family, PLPP2 (phospholipid phosphatase 2) plays a vital role in the occurrence and development of breast cancer, but its mechanism is still unclear. Our research found that PLPP2 was overexpressed in breast cancer, and the higher expression level of PLPP2 showed a worse prognosis for breast cancer patients. Further analysis showed that overexpression of PLPP2 affected the expression of CDC34 (cell-division cycle 34), LSM7 (Like-Smith 7), and SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) through EMT (epigenetic-mesenchymal transition) related pathways to promote the occurrence and development of breast cancer. In vitro, silencing PLPP2 significantly reduced the proliferation, invasion, and migration abilities of human breast cancer cells MDA-MB-231. ER+ is a common subtype of breast cancer. Furthermore, we found that the overexpression of PLPP2 was significantly related to the poor prognosis of ER+ breast cancer. These results indicate that PLPP2 has value as a potential therapeutic target for breast cancer, especially for ER+ breast cancer.
PLPPs（磷脂磷酸酶）广泛表达于不同的人体组织中，调节细胞信号转导，在神经胶质瘤、胰腺腺癌、肺腺癌等癌症中过度表达。PLPP2（磷脂磷酸酶 2）作为 PLPP 家族的一员，在乳腺癌的发生发展中起着至关重要的作用，但作用机制尚不清楚。我们的研究发现 PLPP2 在乳腺癌中过表达，PLPP2 表达水平越高，乳腺癌患者的预后越差。进一步分析表明，PLPP2 的过表达通过 EMT（表观遗传-间质转化）相关途径影响 CDC34（细胞分裂周期 34）、LSM7（Like-Smith 7）和 SGTA（小谷氨酰胺富含四肽重复蛋白 alpha）的表达，从而促进乳腺癌的发生和发展。在体外，沉默 PLPP2 显著降低了人乳腺癌细胞 MDA-MB-231 的增殖、侵袭和迁移能力。ER+是乳腺癌的常见亚型。此外，我们发现 PLPP2 的过表达与 ER+乳腺癌患者的不良预后显著相关。这些结果表明，PLPP2 作为一种潜在的乳腺癌治疗靶点具有价值，特别是对 ER+乳腺癌。
