John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah.
Medical School, Medical College of Wisconsin, Milwaukee, Wisconsin.
Ophthalmology. 2023 Apr;130(4):387-393. doi: 10.1016/j.ophtha.2022.10.028. Epub 2022 Nov 1.
To evaluate the completeness of conflict-of-interest self-reporting by ophthalmology researchers and to assess factors associated with self-reporting.
Cross-sectional observational study.
We evaluated articles published between January and June 2017 in Ophthalmology, JAMA Ophthalmology, the American Journal of Ophthalmology, and Investigative Ophthalmology and Visual Science. To assess more accurately the cases in which an author published multiple articles, we defined a unit of analysis, authorship, for which each author of each article is a unique data point. To enable comparison with the Open Payments Database (OPD), we only included United States physician authorships.
For each authorship, we defined self-reported relationships as the companies listed in the article's conflict-of-interest disclosures. Based on journal policies, we defined OPD-reported relationships as the list of companies that reported payments to the author within 36 months before submission.
For each authorship, we assessed the proportion of OPD-reported relationships that were self-reported. The primary measurement was the proportion of authorships reporting none of their OPD-reported relationships.
Of the 660 total authorships (486 unique authors), 413 authorships (63%) reported none of their OPD-reported relationships, 112 (17%) reported some of them, 9 (1%) reported all of them, and 126 (19%) had 0 relationships. The proportion of authorships reporting none of their relationships did not differ significantly between journals that required reporting of all relationships compared with journals that required reporting only of relevant relationships (adjusted percentage, 61.4% vs. 64.3%; P = 0.46). Authorships with more dollars received during the reporting period showed higher rates of self-reporting (P < 0.001).
Even among journals that required complete reporting, self-reporting was low compared with an industry-maintained database of financial relationships. Deficiencies in reporting may undermine confidence in self-reporting and may compromise the transparency that is needed to interpret research results fairly.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
评估眼科研究人员利益冲突自我报告的完整性，并评估与自我报告相关的因素。
横断面观察性研究。
我们评估了 2017 年 1 月至 6 月期间在《眼科学》《美国医学会眼科杂志》《美国眼科学杂志》和《眼科与视觉科学研究杂志》上发表的文章。为了更准确地评估作者发表多篇文章的情况，我们定义了一个分析单位，即作者，每篇文章的每位作者都是一个独特的数据点。为了与公开支付数据库（Open Payments Database，OPD）进行比较，我们仅纳入了美国医生作者。
对于每个作者，我们将自我报告的关系定义为文章利益冲突披露中列出的公司。根据期刊政策，我们将 OPD 报告的关系定义为在提交前 36 个月内向作者报告的支付款项的公司列表。
对于每个作者，我们评估了 OPD 报告的关系中自我报告的比例。主要测量指标是未报告其 OPD 报告关系的作者比例。
在 660 项总作者（486 位独立作者）中，413 项（63%）未报告其 OPD 报告的任何关系，112 项（17%）报告了部分关系，9 项（1%）报告了全部关系，126 项（19%）无关系。与要求报告所有关系的期刊相比，要求仅报告相关关系的期刊的未报告关系作者比例差异无统计学意义（调整后百分比，61.4%比 64.3%；P=0.46）。在报告期内收到更多款项的作者，其自我报告率更高（P<0.001）。
即使在要求完整报告的期刊中，自我报告率也低于行业维护的财务关系数据库。报告的不足可能会削弱对自我报告的信心，并可能损害公平解释研究结果所需的透明度。
参考文献后可能有专有或商业披露。
