Wright Alexander, Stavres Jon, Galloway Riley, Donahue Paul, Sha Zhanxin, McCoy Stephanie
School of Kinesiology and Nutrition, College of Education and Human Sciences, University of Southern Mississippi, Hattiesburg, MS, USA.
Eur J Appl Physiol. 2023 Mar;123(3):533-546. doi: 10.1007/s00421-022-05079-y. Epub 2022 Nov 5.
Adverse vascular responses can occur during prolonged sitting, including stiffening of the aortic artery which may contribute to cardiovascular disease. Few studies have investigated the impact of intermittent standing and/or prior exercise as strategies to attenuate these potentially deleterious vascular changes.
To investigate central vascular health responses during prolonged sitting, with and without intermittent standing and/or prior exercise.
Fifteen males aged 18 to 31 years were recruited. Subjects completed a control condition [Sitting Only (SO)], and three randomized strategy conditions [Sitting Plus Standing (SSt), Exercise Plus Sitting (ES), Exercise Plus Sitting Plus Standing (ESSt)]. For all conditions, measurements of carotid-femoral pulse wave velocity (cfPWV) were taken at pre- and post-intervention, and brachial and central blood pressure (BP) at pre-, 1-h, 2-h, and 3-h intervention.
cfPWV significantly increased from pre- to post-intervention for all conditions (all p ≤ 0.043), as did brachial mean arterial pressure (MAP) and diastolic BP, and central MAP and diastolic BP for the control condition (all p ≤ 0.022). Brachial and central systolic BP were significantly higher during SO compared to ESSt at 1 h, and compared to ES for central systolic BP (all p ≤ 0.036).
Strategies of intermittent standing and/or prior exercise may not prevent aortic stiffening during sitting but may attenuate BP elevations in the brachial and aortic arteries. Future research should investigate causal mechanistic links between sitting and aortic stiffening, and other attenuation strategies.
长时间坐着时可能会出现不良血管反应，包括主动脉僵硬，这可能会导致心血管疾病。很少有研究调查间歇性站立和/或先前运动作为减轻这些潜在有害血管变化的策略的影响。
研究在长时间坐着期间，有无间歇性站立和/或先前运动时的中心血管健康反应。
招募了15名年龄在18至31岁之间的男性。受试者完成了一个对照条件[仅坐着（SO）]，以及三个随机策略条件[坐着加站立（SSt）、运动加坐着（ES）、运动加坐着加站立（ESSt）]。对于所有条件，在干预前和干预后测量颈股脉搏波速度（cfPWV），并在干预前、1小时、2小时和3小时测量肱动脉和中心血压（BP）。
所有条件下，cfPWV从干预前到干预后均显著增加（所有p≤0.043），对照条件下肱动脉平均动脉压（MAP）和舒张压BP以及中心MAP和舒张压BP也显著增加（所有p≤0.022）。在1小时时，与ESSt相比，SO期间肱动脉和中心收缩压显著更高，与ES相比，中心收缩压也显著更高（所有p≤0.036）。
间歇性站立和/或先前运动的策略可能无法预防坐着时的主动脉僵硬，但可能会减轻肱动脉和主动脉的血压升高。未来的研究应调查坐着与主动脉僵硬之间的因果机制联系以及其他减轻策略。
