Chen Dan, Zhou Xuebing, Yan PengYu, Yang Chunyu, Li Yuan, Han Longzhe, Ren Xiangshan
Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji, China.
Key Laboratory of Pathobiology, Yanbian University, State Ethnic Affairs Commission, Yanji, China.
J Cell Biochem. 2023 Jan;124(1):3-16. doi: 10.1002/jcb.30347. Epub 2022 Nov 5.
The hallmark feature of metabolic reprogramming is now considered to be widespread in many malignancies, including colorectal cancer (CRC). Of the gastrointestinal tumors, CRC is one of the most common with a high metastasis rate and long insidious period. The incidence and mortality of CRC has increased in recent years. Metabolic reprogramming also has a significant role in the development and progression of CRC, especially lipid metabolic reprogramming. Many studies have reported that lipid metabolism reprogramming is similar to the Warburg effect with typical features affecting tumor biology including proliferation, migration, local invasion, apoptosis, and other biological behaviors of cancer cells. Therefore, studying the role of lipid metabolism in the occurrence and development of CRC will increase our understanding of its pathogenesis, invasion, metastasis, and other processes and provide new directions for the treatment of CRC. In this paper, we mainly describe the molecular mechanism of lipid metabolism reprogramming and its important role in the occurrence and development of CRC. In addition, to provide reference for subsequent research and clinical diagnosis and treatment we also review the treatments of CRC that target lipid metabolism.
代谢重编程的标志性特征目前被认为在包括结直肠癌（CRC）在内的许多恶性肿瘤中广泛存在。在胃肠道肿瘤中，CRC是最常见的肿瘤之一，具有高转移率和长潜伏期。近年来，CRC的发病率和死亡率有所上升。代谢重编程在CRC的发生和发展中也起着重要作用，尤其是脂质代谢重编程。许多研究报道，脂质代谢重编程类似于瓦伯格效应，具有影响肿瘤生物学的典型特征，包括癌细胞的增殖、迁移、局部侵袭、凋亡和其他生物学行为。因此，研究脂质代谢在CRC发生发展中的作用将增进我们对其发病机制、侵袭、转移及其他过程的理解，并为CRC的治疗提供新的方向。在本文中，我们主要描述脂质代谢重编程的分子机制及其在CRC发生发展中的重要作用。此外，为后续研究及临床诊断和治疗提供参考，我们还综述了针对脂质代谢的CRC治疗方法。
