Wang Yiyi, Wu Yangyang, Zheng Feixue, Zhang Ting, Wang Meng, Huang Lei, Fan Xiaolong, Chen Jinsheng, Xiao Naian
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
Aerosol and Haze Laboratory, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Environ Int. 2022 Dec;170:107604. doi: 10.1016/j.envint.2022.107604. Epub 2022 Oct 28.
Environmental pollution of trace elements has become of main concern due to the adverse effects. To estimate the impact of PM-bound trace elements on human health, a time-stratified case-crossover study has been designed to examine the short-term associations between 28 elements and asthma hospitalizations from January 2019 to November 2021 in Xiamen, China. This research summarized the major components that pose health risks in different seasons and took risk assessment for different groups. We found that an inter-quartile range (IQR) increase of Ca, Fe, Mn, Pd, Si, and Ti was positively associated with the incidence of asthma in the lag of 0-4 days. In winter, the elements that predisposed the population to asthma attack were the most, such as Al, Ba, Ca, Cr, Cu, Fe, K, Mn, Pd, Si, and Ti, and these elements are at higher risk for longer periods of time. The discrepancy in risk levels and major elements of asthma diagnosis among various age groups were also found in this work. Our results provided insights into the development of specific policies to reduce the risk of asthma attacks due to exposure to PM-bound trace elements.
由于微量元素的环境污染会产生不利影响，它已成为主要关注点。为了评估与颗粒物结合的微量元素对人类健康的影响，设计了一项时间分层病例交叉研究，以检验2019年1月至2021年11月期间中国厦门28种元素与哮喘住院之间的短期关联。本研究总结了不同季节中构成健康风险的主要成分，并对不同群体进行了风险评估。我们发现，钙、铁、锰、钯、硅和钛的四分位数间距（IQR）增加与0 - 4天滞后的哮喘发病率呈正相关。在冬季，使人群易患哮喘发作的元素最多，如铝、钡、钙、铬、铜、铁、钾、锰、钯、硅和钛，并且这些元素在较长时间内处于较高风险。这项研究还发现了不同年龄组在哮喘诊断风险水平和主要元素方面的差异。我们的结果为制定具体政策以降低因接触与颗粒物结合的微量元素而导致哮喘发作的风险提供了见解。
