Department of Respiratory Medicine, Graduate School of Medicine Kyoto University, 54 Shogoin, Kawaharamachi, Sakyo-ku, Kyoto City, Kyoto, Japan.
Department of Respiratory Medicine, Graduate School of Medicine Kyoto University, 54 Shogoin, Kawaharamachi, Sakyo-ku, Kyoto City, Kyoto, Japan; Department of Respiratory Medicine & Allergology, Faculty of Medicine Kindai University, 377-2, Ohno-Higashi, Osakasayama City, Osaka, Japan.
Respir Investig. 2023 Jan;61(1):23-26. doi: 10.1016/j.resinv.2022.09.006. Epub 2022 Nov 2.
Staphylococcus aureus (S. aureus) is an inducer of mucosal type 2 immune response. To test the hypothesis that airway colonization with S. aureus may reflect allergic predisposition with staphylococcal enterotoxin (SE) sensitization in bronchiectasis, we retrospectively examined the association between SE sensitization and S. aureus and Pseudomonas aeruginosa (P. aeruginosa) in sputum of patients with bronchiectasis (n = 35). Overall, 14 (40%) patients with bronchiectasis were sensitized to either staphylococcal enterotoxin A (SEA) or staphylococcal enterotoxin B (SEB). SEA sensitization was more frequently observed in patients with sputum S. aureus than those without it. Patients with sputum S. aureus but without P. aeruginosa exhibited the highest SEA sensitization frequency and serum total IgE levels. Patients with both S. aureus and P. aeruginosa exhibited the highest blood eosinophils. In conclusion, S. aureus in the lower airway may indicate an allergic predisposition with SE sensitization and blood eosinophilia in bronchiectasis.
金黄色葡萄球菌（S. aureus）是黏膜 2 型免疫反应的诱导剂。为了验证气道定植金黄色葡萄球菌可能反映支气管扩张症中金黄色葡萄球菌肠毒素（SE）致敏的过敏倾向的假设，我们回顾性地研究了支气管扩张症患者痰液中 SE 致敏与金黄色葡萄球菌和铜绿假单胞菌（P. aeruginosa）之间的关联（n=35）。总体而言，14 名（40%）支气管扩张症患者对金黄色葡萄球菌肠毒素 A（SEA）或金黄色葡萄球菌肠毒素 B（SEB）有敏感性。痰液中存在金黄色葡萄球菌的患者比不存在金黄色葡萄球菌的患者更常出现 SEA 致敏。痰液中存在金黄色葡萄球菌但不存在铜绿假单胞菌的患者表现出最高的 SEA 致敏频率和血清总 IgE 水平。同时存在金黄色葡萄球菌和铜绿假单胞菌的患者血液嗜酸性粒细胞最高。总之，下呼吸道中的金黄色葡萄球菌可能表明支气管扩张症中存在 SE 致敏和嗜酸性粒细胞增多的过敏倾向。
