Department of Respiratory and Critical Care Medicine, Research Center for Chronic Airway Diseases, Peking University Third Hospital, Peking University Health Science Center, Beijing, China.
BMC Pulm Med. 2023 Aug 31;23(1):316. doi: 10.1186/s12890-023-02607-0.
Our study aimed to investigate whether serum total IgE and blood eosinophils were associated with radiological features of bronchiectasis in a Chinese cohort.
We retrospectively enrolled bronchiectasis patients who visited Peking University Third Hospital from Jan 1, 2012 to Oct 7, 2021. The clinical, laboratory and chest CT characteristics were analyzed in association with serum total IgE level and blood eosinophil count.
A total of 125 bronchiectasis patients were enrolled, with 50.4% (63/125) female, and a mean age of 62.4 ± 14.1 years. The median serum total IgE level and blood eosinophil count were 47.7 (19.8, 123.0) KU/L and 140 (90, 230) cells/µl, respectively. In patients with a higher than normal (normal range, 0-60 KU/L) total IgE (43.2%, n = 54), more lobes were involved [4 (3, 5) vs. 3 (2, 4), p = 0.008], and mucus plugs were more common (25.9% vs. 9.9%, p =0.017) on HRCT, as compared to those with a normal level of total IgE. The higher IgE group was more likely to have bilateral involvement (p = 0.059), and had numerically higher Smith and Bhalla scores, but the differences were not statistically significant. In patients with an eosinophil count ≥ 150 cells/µl (49.6%, n = 62), the number of lobes involved was greater [4 (3, 5) vs. 3 (2, 4), p = 0.015], and the Smith and Bhalla scores were higher [9 (5, 12) vs. 6 (3, 9), p = 0.009, 7 (5, 11) vs. 5 (3, 9), p = 0.036]. The Smith score was correlated positively with the eosinophil count (r = 0.207, p = 0.020). Fractional exhaled nitric oxide (FeNO) was correlated with total IgE (r = 0.404, p = 0.001) and eosinophil count (r = 0.310, p = 0.014).
Our study demonstrated that serum total IgE and the blood eosinophil count were associated with the radiological extent and severity of bronchiectasis, necessitating further investigation on the role of T2 inflammation in structural abnormalities of this heterogeneous disease.
本研究旨在探讨血清总 IgE 和血嗜酸性粒细胞是否与中国队列支气管扩张的影像学特征有关。
我们回顾性纳入了 2012 年 1 月 1 日至 2021 年 10 月 7 日期间在北京大学第三医院就诊的支气管扩张症患者。分析了临床、实验室和胸部 CT 特征与血清总 IgE 水平和血嗜酸性粒细胞计数的关系。
共纳入 125 例支气管扩张症患者，其中 50.4%（63/125）为女性，平均年龄为 62.4±14.1 岁。中位血清总 IgE 水平和血嗜酸性粒细胞计数分别为 47.7（19.8，123.0）KU/L 和 140（90，230）细胞/µl。在总 IgE 高于正常值（正常值范围：0-60KU/L）的患者中（43.2%，n=54），受累肺叶更多[4（3，5）比 3（2，4），p=0.008]，HRCT 上更常见黏液嵌塞（25.9%比 9.9%，p=0.017）。与总 IgE 水平正常的患者相比，高 IgE 组更有可能出现双侧受累（p=0.059），Smith 和 Bhalla 评分更高，但差异无统计学意义。在嗜酸性粒细胞计数≥150 细胞/µl 的患者中（49.6%，n=62），受累肺叶数更多[4（3，5）比 3（2，4），p=0.015]，Smith 和 Bhalla 评分更高[9（5，12）比 6（3，9），p=0.009，7（5，11）比 5（3，9），p=0.036]。Smith 评分与嗜酸性粒细胞计数呈正相关（r=0.207，p=0.020）。呼出气一氧化氮分数（FeNO）与总 IgE（r=0.404，p=0.001）和嗜酸性粒细胞计数（r=0.310，p=0.014）呈正相关。
本研究表明，血清总 IgE 和血嗜酸性粒细胞计数与支气管扩张的影像学范围和严重程度有关，需要进一步研究 T2 炎症在这种异质性疾病的结构异常中的作用。
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