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葡萄球菌肠毒素B（SEB）类毒素对大鼠全身感染期间肺和肝组织完整性的保护作用。

Protective effects of Staphylococcal Enterotoxin B (SEB) toxoid on lung and liver tissue integrity in rats during systemic infection.

作者信息

Al-Fetly Dhafer Rasheed, Rhyaf Atiaf Ghanim, Naji Hala Abbas

机构信息

Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Diwaniyah, Iraq.

Department of Pathology, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Diwaniyah, Iraq.

出版信息

Iran J Microbiol. 2025 Apr;17(2):220-228. doi: 10.18502/ijm.v17i2.18396.

DOI:10.18502/ijm.v17i2.18396
PMID:40337679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12053421/
Abstract

BACKGROUND AND OBJECTIVES

Staphylococcal enterotoxin B (SEB), a potent superantigenic toxin produced by , plays a crucial role in systemic infection. This investigation sought to determine whether immunising animals with SEB toxoid could protect against an experimental acute systemic infection caused by

MATERIALS AND METHODS

This study involved three groups of animals: one group was administered with SEB toxoid, and the second group was administered with intramuscular injections of normal saline, after which both were subjected to systemic infection. The third group served as the negative control. After two weeks, the outcomes of the experimental systemic infection demonstrated that SEB immunisation significantly shielded organs (lung and liver) from damage in comparison to the control group.

RESULTS

Regarding the histopathological analysis of liver and lung tissues, the control group showed minimal alterations, indicating a normal tissue state. Infected individuals exhibited severe pathology, including inflammation, necrosis, and fibrosis. The immunised group displayed a mixed profile with elevated inflammation but lower necrosis and fibrosis. Immunisation mitigated pathological changes induced by infection, fostering a more controlled response.

CONCLUSION

SEB plays an important role in pathogenesis and immunisation, and this toxoid might protect against fatal infections of

摘要

背景与目的

葡萄球菌肠毒素B（SEB）是由[未提及的细菌]产生的一种强效超抗原毒素，在全身感染中起关键作用。本研究旨在确定用SEB类毒素免疫动物是否能预防由[未提及的病原体]引起的实验性急性全身感染。

材料与方法

本研究涉及三组动物：一组给予SEB类毒素，第二组肌肉注射生理盐水，之后两组均遭受全身感染。第三组作为阴性对照。两周后，实验性全身感染的结果表明，与对照组相比，SEB免疫显著保护器官（肺和肝）免受损伤。

结果

关于肝和肺组织的组织病理学分析，对照组显示变化极小，表明组织状态正常。感染个体表现出严重病变，包括炎症、坏死和纤维化。免疫组呈现混合情况，炎症增加但坏死和纤维化程度较低。免疫减轻了感染引起的病理变化，促进了更可控的反应。

结论

SEB在[未提及的病原体]发病机制和免疫中起重要作用，这种类毒素可能预防[未提及的病原体]的致命感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/bb83d09ee739/IJM-17-220-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/d1d4f1a409af/IJM-17-220-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/3035ccb9ab84/IJM-17-220-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/c12e3bf0b9ca/IJM-17-220-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/300d6ff69c6e/IJM-17-220-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/f5bf1bc6c0d5/IJM-17-220-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/97b4e1672619/IJM-17-220-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/bb83d09ee739/IJM-17-220-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/d1d4f1a409af/IJM-17-220-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/3035ccb9ab84/IJM-17-220-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/c12e3bf0b9ca/IJM-17-220-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/300d6ff69c6e/IJM-17-220-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/f5bf1bc6c0d5/IJM-17-220-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/97b4e1672619/IJM-17-220-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8943/12053421/bb83d09ee739/IJM-17-220-g007.jpg

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