DNA 损伤和双链断裂概述。
Overview of DNA damage and double-strand breaks.
机构信息
Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan.
Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
出版信息
Enzymes. 2022;51:1-5. doi: 10.1016/bs.enz.2022.08.001. Epub 2022 Oct 7.
DNA is under a variety of assaults. As a result, different damages accumulate on DNA. These include base changes, single-strand breaks and double-strand breaks. In this volume and also briefly in the following volume, we discuss DNA damage and double-strand breaks. In particular, we focus on double-strand breaks. We discuss types of double-strand breaks as well as methods to detect them. We also discuss how DNA breaks are formed.
DNA 受到多种攻击。结果，DNA 上会累积不同的损伤。这些损伤包括碱基改变、单链断裂和双链断裂。在这一卷中，以及在下一卷中也会简要讨论，我们讨论 DNA 损伤和双链断裂。特别是，我们重点关注双链断裂。我们讨论双链断裂的类型以及检测它们的方法。我们还讨论了 DNA 断裂是如何形成的。
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