Ren Shuhua, Hu Jingchao, Huang Lin, Li Junpeng, Jiang Donglang, Hua Fengchun, Guan Yihui, Guo Qihao, Xie Fang, Huang Qi
PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
J Alzheimers Dis. 2022;90(4):1749-1759. doi: 10.3233/JAD-220527.
Subjects with subjective cognitive decline (SCD) are proposed as a potential population to screen for Alzheimer's disease (AD).
Investigating brain topologies would help to mine the neuromechanisms of SCD and provide new insights into the pathogenesis of AD.
Objectively cognitively unimpaired subjects from communities who underwent resting-state BOLD-fMRI and clinical assessments were included. The subjects were categorized into SCD and normal control (NC) groups according to whether they exhibited self-perceived cognitive decline and were worried about it. The minimum spanning tree (MST) of the functional brain network was calculated for each subject, based on which the efficiency and centrality of the brain network organization were explored. Hippocampal/parahippocampal volumes were also detected to reveal whether the early neurodegeneration of AD could be seen in SCD.
A total of 49 subjects in NC and 95 subjects in SCD group were included in this study. We found the efficiency and centrality of brain network organization, as well as the hippocampal/parahippocampal volume were preserved in SCD. Besides, SCD exhibited normal cognitions, including memory, language, and execution, but increased depressive and anxious levels. Interestingly, language and execution, instead of memory, showed a significant positive correlation with the maximum betweenness centrality of the functional brain organization and hippocampal/parahippocampal volume. Neither depressive nor anxious scales exhibited correlations with the brain functional topologies or hippocampal/parahippocampal volume.
SCD exhibited preserved efficiency and centrality of brain organization. In clinical practice, language and execution as well as depression and anxiety should be paid attention in SCD.
主观认知下降（SCD）的受试者被提议作为筛查阿尔茨海默病（AD）的潜在人群。
研究脑拓扑结构有助于挖掘SCD的神经机制，并为AD的发病机制提供新的见解。
纳入来自社区的客观认知未受损且接受静息态BOLD-fMRI和临床评估的受试者。根据受试者是否表现出自我感知的认知下降并为此担忧，将其分为SCD组和正常对照组（NC）。计算每个受试者功能脑网络的最小生成树（MST），并据此探索脑网络组织的效率和中心性。还检测海马/海马旁回体积，以揭示SCD中是否可见AD的早期神经退行性变。
本研究共纳入49名NC受试者和95名SCD组受试者。我们发现SCD组脑网络组织的效率和中心性以及海马/海马旁回体积均得以保留。此外，SCD表现出正常的认知功能，包括记忆、语言和执行功能，但抑郁和焦虑水平增加。有趣的是，语言和执行功能而非记忆功能，与功能脑组织结构的最大介数中心性和海马/海马旁回体积呈显著正相关。抑郁和焦虑量表与脑功能拓扑结构或海马/海马旁回体积均无相关性。
SCD组脑组织结构的效率和中心性得以保留。在临床实践中，SCD患者应关注语言、执行功能以及抑郁和焦虑情况。
