Danger Brook, Ripplinger Christopher, Blondeau Joseph, Blondeau Leah, Peermohamed Shaqil
Internal Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Clinical Microbiology, Saskatchewan Health Authority, Saskatoon, Saskatchewan, Canada.
J Assoc Med Microbiol Infect Dis Can. 2022 Jun 3;7(2):146-149. doi: 10.3138/jammi-2021-0027. eCollection 2022 Jun.
We report a rare case of bacteremia and polyarticular septic arthritis in a 37-year-old pregnant woman with HIV who injects drugs. Two sets of blood cultures obtained 5 hours apart were positive for gram-negative bacilli, and purulent fluid was present intra-operatively from both her left knee and her right third MCP joints.
Organism identification using ligation sequencing confirmed both her blood culture and synovial tissue isolates as . Her infection was initially treated with third-generation cephalosporins and later changed to moxifloxacin because of a drug reaction; although she defervesced clinically with improvement in her C-reactive protein levels, she died most likely as a result of a non-traumatic fat embolism after an elective cesarean delivery.
In contrast to , other species are rarely associated with disease in human hosts. is classically associated with infectious bovine keratoconjunctivitis in cattle; interestingly, our patient denied significant animal exposure. To the authors' knowledge, this is the first case describing infection secondary to in an adult host.
我们报告了一例罕见的菌血症和多关节化脓性关节炎病例，患者为一名37岁的感染艾滋病毒且注射毒品的孕妇。间隔5小时采集的两组血培养物革兰氏阴性杆菌呈阳性，术中其左膝和右第三掌指关节均有脓性液体。
使用连接测序进行的微生物鉴定证实其血培养物和滑膜组织分离物均为 。她的感染最初用第三代头孢菌素治疗，后来因药物反应改为莫西沙星治疗；尽管她临床退热且C反应蛋白水平有所改善，但她很可能在择期剖宫产术后死于非创伤性脂肪栓塞。
与 不同，其他 菌种很少在人类宿主中引发疾病。 通常与牛的感染性牛角膜结膜炎有关；有趣的是，我们的患者否认有大量动物接触史。据作者所知，这是第一例描述成年宿主继发 感染的病例。
