Gao Ting, Liu Fupeng, Ban Bo, Hou Yue, Li Guangxin, Jiang Mingming, Yang Qing, Zhang Mei
Department of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Front Nutr. 2022 Oct 21;9:1035853. doi: 10.3389/fnut.2022.1035853. eCollection 2022.
The ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).
This cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured.
Pearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS ( = 0.170, = 0.001), FN ( = 0.178, < 0.001), and TH ( = 0.205, < 0.001). The results of stepwise linear regression suggested that Cre/CysC was the only biochemical predictor of the BMD at three sites (LS: β = 0.137, = 0.01; FN: β = 0.097, = 0.038; TH: β = 0.145, = 0.002).
In older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis.
肌酐与胱抑素C的比值（Cre/CysC）是肌肉功能和肌肉量的标志物，可用于预测不同人群的肌肉减少症。由于肌肉减少症与骨质疏松症密切相关，本研究调查了2型糖尿病（T2DM）患者中Cre/CysC与骨密度（BMD）之间的关联。
这项横断面研究纳入了391例中国T2DM患者。测量了一般信息、生化指标以及腰椎（LS）、股骨颈（FN）和全髋（TH）的骨密度。
Pearson相关性分析显示，Cre/CysC与LS的骨密度显著正相关（=0.170，=0.001），与FN的骨密度显著正相关（=0.178，<0.001），与TH的骨密度显著正相关（=0.205，<0.001）。逐步线性回归结果表明，Cre/CysC是三个部位骨密度的唯一生化预测指标（LS：β=0.137，=0.01；FN：β=0.097，=0.038；TH：β=0.145，=0.002）。
在老年T2DM患者中，高Cre/CysC值与骨密度独立正相关，因此，Cre/CysC可能是骨质疏松症的一个有价值的标志物。
