梨渣可溶性膳食纤维通过调节肠道微生物群和相关代谢产物改善高脂饮食对小鼠的负面影响。

Pear pomace soluble dietary fiber ameliorates the negative effects of high-fat diet in mice by regulating the gut microbiota and associated metabolites.

作者信息

Ji Yuehong, Mao Kemin, Gao Jie, Chitrakar Bimal, Sadiq Faizan Ahmed, Wang Zhongxuan, Wu Jiangna, Xu Chao, Sang Yaxin

机构信息

College of Food Science and Technology, Hebei Agricultural University, Baoding, China.

Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), Technology and Food Sciences Unit, Melle, Belgium.

出版信息

Front Nutr. 2022 Oct 20;9:1025511. doi: 10.3389/fnut.2022.1025511. eCollection 2022.

The gut microbiota and related metabolites are positively regulated by soluble dietary fiber (SDF). In this study, we explored the effects of SDF from pear pomace (PP) on the regulation of gut microbiota and metabolism in high-fat-diet-fed (HFD-fed) C57BL/6J male mice. The results showed that PP-SDF was able to maintain the HFD disrupted gut microbiota diversity with a significant increase in _UCG-006, , and spp. The negative effects of high-fat diet were ameliorated by PP-SDF by regulating lipid metabolisms with a significant increase in metabolites like isobutyryl carnitine and dioscoretine. Correlation analysis revealed that gut microbiota, such as and _UCG-006 in the PP-SDF intervention groups had strong positive correlations with isobutyryl carnitine and dioscoretin. These findings demonstrated that PP-SDF interfered with the host's gut microbiota and related metabolites to reduce the negative effects caused by a high-fat diet.

肠道微生物群及其相关代谢产物受到可溶性膳食纤维（SDF）的正向调节。在本研究中，我们探究了梨渣（PP）中的SDF对高脂饮食喂养（HFD喂养）的C57BL/6J雄性小鼠肠道微生物群调节和代谢的影响。结果表明，PP-SDF能够维持HFD破坏的肠道微生物群多样性，_UCG-006、和菌属显著增加。PP-SDF通过调节脂质代谢改善了高脂饮食的负面影响，异丁酰肉碱和薯蓣皂素等代谢产物显著增加。相关性分析显示，PP-SDF干预组中的肠道微生物群，如和_UCG-006与异丁酰肉碱和薯蓣皂素具有很强的正相关性。这些发现表明，PP-SDF通过干扰宿主的肠道微生物群及其相关代谢产物来减少高脂饮食造成的负面影响。