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酮症倾向型糖尿病:一种住院医师需要了解的表型。

Ketosis-prone diabetes mellitus: A phenotype that hospitalists need to understand.

作者信息

Boike Sydney, Mir Mikael, Rauf Ibtisam, Jama Abbas B, Sunesara Shaleen, Mushtaq Hisham, Khedr Anwar, Nitesh Jain, Surani Salim, Khan Syed A

机构信息

Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, United States.

Medicine, St. George's School of Medicine, Grenada FZ818, West Indies.

出版信息

World J Clin Cases. 2022 Oct 26;10(30):10867-10872. doi: 10.12998/wjcc.v10.i30.10867.

DOI:10.12998/wjcc.v10.i30.10867
PMID:36338201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9631166/
Abstract

Diabetes has been classified mainly into types 1 and 2. Some type 2 diabetes patients, when developing ketosis, have been labeled as having atypical diabetes. Lately, syndromes of ketosis-prone diabetes, primarily in patients who we previously classified as type 2 diabetics, have emerged, and calls are being made to even reclassify diabetes. This mini-review will extensively deal with the historical, molecular, phenotypical, and clinical basis of why ketosis-prone diabetes is different than the traditional principles of type 1 and 2 diabetes and should be classified as such. Clinicians, especially those who are not diabetologists or endocrinologists, as well as hospitalists, intensivists, and primary care providers, will greatly benefit from this review.

摘要

糖尿病主要分为1型和2型。一些2型糖尿病患者在出现酮症时,被标记为患有非典型糖尿病。最近,酮症倾向糖尿病综合征出现了,主要发生在我们之前归类为2型糖尿病的患者中,甚至有人呼吁对糖尿病进行重新分类。这篇小型综述将广泛探讨酮症倾向糖尿病不同于1型和2型糖尿病传统定义的历史、分子、表型和临床依据,以及为何应如此分类。临床医生,尤其是那些非糖尿病专家或内分泌专家的医生,以及住院医生、重症监护医生和初级保健提供者,将从这篇综述中受益匪浅。

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本文引用的文献

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Diabetic ketoacidosis in pregnancy - Case series, pathophysiology, and review of the literature.妊娠期糖尿病酮症酸中毒——病例系列、病理生理学及文献复习。
Eur J Obstet Gynecol Reprod Biol. 2022 Feb;269:41-46. doi: 10.1016/j.ejogrb.2021.12.011. Epub 2021 Dec 21.
2
Improving Ketosis-Prone Type 2 Diabetes Diagnosis in Africa.改善非洲酮症倾向2型糖尿病的诊断
MEDICC Rev. 2021 Jul-Oct;23(3-4):61-62. doi: 10.37757/MR2021.V23.N3.11. Epub 2021 Aug 22.
3
Metabolomics Profiling of Patients With A-β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis.β-羟丁酸阳性酮症倾向糖尿病患者糖尿病酮症酸中毒期间的代谢组学分析。
Diabetes. 2021 Aug;70(8):1898-1909. doi: 10.2337/db21-0066. Epub 2021 May 21.
4
Onset of Ketosis-Prone Diabetes in the Setting of COVID-19 Infection.2019冠状病毒病感染背景下酮症倾向糖尿病的发病情况
Cureus. 2020 Oct 3;12(10):e10779. doi: 10.7759/cureus.10779.
5
Ketosis-Prone Type 2 Diabetes: A Case Series.酮症倾向2型糖尿病:病例系列
Front Endocrinol (Lausanne). 2019 Oct 16;10:684. doi: 10.3389/fendo.2019.00684. eCollection 2019.
6
Diabetic ketoacidosis: update on management.糖尿病酮症酸中毒:治疗进展。
Clin Med (Lond). 2019 Sep;19(5):396-398. doi: 10.7861/clinmed.2019-0284.
7
Ketosis-Prone Diabetes (Flatbush Diabetes): an Emerging Worldwide Clinically Important Entity.酮症倾向糖尿病(弗拉特布什糖尿病):一种在全球范围内具有重要临床意义的新兴疾病。
Curr Diab Rep. 2018 Oct 2;18(11):120. doi: 10.1007/s11892-018-1075-4.
8
Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.升高的非甲基化和甲基化胰岛素 DNA 是 A+β+酮症倾向糖尿病的独特标志物。
J Diabetes Complications. 2018 Feb;32(2):193-195. doi: 10.1016/j.jdiacomp.2017.10.013. Epub 2017 Oct 31.
9
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Endocr Pract. 2017 Aug;23(8):971-978. doi: 10.4158/EP161679.RA. Epub 2017 May 23.
10
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Clin Diabetes. 2015 Jul;33(3):150-1. doi: 10.2337/diaclin.33.3.150.