升高的非甲基化和甲基化胰岛素 DNA 是 A+β+酮症倾向糖尿病的独特标志物。
Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.
机构信息
Department of Medicine, Section of Diabetes and Endocrinology, Baylor College of Medicine, Houston, TX, USA.
Center for Diabetes and Metabolic Diseases, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
J Diabetes Complications. 2018 Feb;32(2):193-195. doi: 10.1016/j.jdiacomp.2017.10.013. Epub 2017 Oct 31.
Abstract
A+β+ ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevated in A+β+ KPD compared to all other KPD subgroups.
摘要
A+β+酮症倾向糖尿病（KPD）与缓慢进展的自身免疫性β细胞破坏有关。与其他所有 KPD 亚组相比，A+β+KPD 患者的血浆未甲基化和甲基化胰岛素 DNA（分别为持续的β细胞损伤和全身炎症的生物标志物）升高。
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本文引用的文献
1
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J Vis Exp. 2016 Dec 21(118):54838. doi: 10.3791/54838.
2
Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.新发1型糖尿病患者循环中甲基化和未甲基化前胰岛素原DNA水平升高。
Diabetes. 2015 Nov;64(11):3867-72. doi: 10.2337/db15-0430. Epub 2015 Jul 27.
3
Factors associated with early relapse to insulin dependence in unprovoked A-β+ ketosis-prone diabetes.非诱因性A-β+酮症倾向糖尿病早期复发至胰岛素依赖的相关因素。
J Diabetes Complications. 2015 Sep-Oct;29(7):918-22. doi: 10.1016/j.jdiacomp.2015.04.013. Epub 2015 Apr 30.
4
Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.通过差异甲基化 DNA 的多重 PCR 分析检测体内胰岛 β 细胞死亡。
Endocrinology. 2013 Sep;154(9):3476-81. doi: 10.1210/en.2013-1223. Epub 2013 Jul 3.
5
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6
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Endocr Rev. 2008 May;29(3):292-302. doi: 10.1210/er.2007-0026. Epub 2008 Feb 21.
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