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升高的非甲基化和甲基化胰岛素 DNA 是 A+β+酮症倾向糖尿病的独特标志物。

Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.

机构信息

Department of Medicine, Section of Diabetes and Endocrinology, Baylor College of Medicine, Houston, TX, USA.

Center for Diabetes and Metabolic Diseases, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

出版信息

J Diabetes Complications. 2018 Feb;32(2):193-195. doi: 10.1016/j.jdiacomp.2017.10.013. Epub 2017 Oct 31.

DOI:10.1016/j.jdiacomp.2017.10.013
PMID:29175121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6170161/
Abstract

A+β+ ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevated in A+β+ KPD compared to all other KPD subgroups.

摘要

A+β+酮症倾向糖尿病（KPD）与缓慢进展的自身免疫性β细胞破坏有关。与其他所有 KPD 亚组相比，A+β+KPD 患者的血浆未甲基化和甲基化胰岛素 DNA（分别为持续的β细胞损伤和全身炎症的生物标志物）升高。

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Diabetes Care. 2023 Jun 1;46(6):1265-1270. doi: 10.2337/dc22-2440.
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Ketosis-prone diabetes mellitus: A phenotype that hospitalists need to understand.酮症倾向型糖尿病：一种住院医师需要了解的表型。

本文引用的文献

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Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death.测量人血清样本中差异甲基化的胰岛素（INS）DNA种类作为胰岛β细胞死亡的生物标志物。
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Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.新发1型糖尿病患者循环中甲基化和未甲基化前胰岛素原DNA水平升高。
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Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison.循环非甲基化胰岛素 DNA 作为人类胰岛 β 细胞死亡的生物标志物：多实验室检测比较。
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SYNDROMES OF KETOSIS-PRONE DIABETES.酮症倾向糖尿病综合征
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Biomarkers of islet beta cell stress and death in type 1 diabetes.1 型糖尿病胰岛β细胞应激和死亡的生物标志物。
Diabetologia. 2018 Nov;61(11):2259-2265. doi: 10.1007/s00125-018-4712-1. Epub 2018 Aug 15.
非诱因性A-β+酮症倾向糖尿病早期复发至胰岛素依赖的相关因素。
J Diabetes Complications. 2015 Sep-Oct;29(7):918-22. doi: 10.1016/j.jdiacomp.2015.04.013. Epub 2015 Apr 30.
4
Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.通过差异甲基化 DNA 的多重 PCR 分析检测体内胰岛 β 细胞死亡。
Endocrinology. 2013 Sep;154(9):3476-81. doi: 10.1210/en.2013-1223. Epub 2013 Jul 3.
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Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19018-23. doi: 10.1073/pnas.1111008108. Epub 2011 Nov 9.
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