CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Oxid Med Cell Longev. 2022 Oct 28;2022:5748924. doi: 10.1155/2022/5748924. eCollection 2022.
Tardive dyskinesia (TD) is a prevalent movement disorder that significantly impacts patients with schizophrenia (SCZ) due to extended exposure to antipsychotics (AP). Several genetic polymorphisms, including superoxide dismutase (SOD) and DRD3 9ser, have been suggested as explanations why some patients suffer from TD. . A PubMed search was used to search relevant articles using the following keywords: "Tardive Dyskinesia and Superoxide Dismutase". Fifty-eight articles were retrieved. Among them, 16 were included in this review. . Overall, 58 studies were retrieved from PubMed. Most studies investigated the association between TD and the SOD-related polymorphisms. In addition, previous studies reported an association between TD occurrence and other genetic polymorphisms. . This study found that the risk of TD is associated with altered SOD levels and several genetic polymorphisms, including VAL 66 Met and DRD3 9ser.
迟发性运动障碍（TD）是一种普遍的运动障碍，由于长期接触抗精神病药（AP），它会严重影响精神分裂症（SCZ）患者。一些遗传多态性，包括超氧化物歧化酶（SOD）和 DRD3 9ser，被认为是一些患者患有 TD 的原因。使用 PubMed 搜索了以下关键词的相关文章：“迟发性运动障碍和超氧化物歧化酶”。检索到 58 篇文章。其中，16 篇文章被纳入本综述。总体而言，从 PubMed 检索到 58 项研究。大多数研究调查了 TD 与 SOD 相关多态性之间的关系。此外，先前的研究报告了 TD 发生与其他遗传多态性之间的关联。本研究发现，TD 的风险与 SOD 水平的改变和几个遗传多态性有关，包括 VAL66Met 和 DRD39ser。
