Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh.
Department of Chemistry, University of Swabi, Swabi, Pakistan.
Crit Rev Food Sci Nutr. 2022;62(26):7282-7300. doi: 10.1080/10408398.2021.1913400. Epub 2021 Apr 27.
Many short-lived and highly reactive oxygen species, such as superoxide anion (O) and hydrogen peroxide (HO), are toxic or can create oxidative stress in cells, a response involved in the pathogenesis of numerous diseases depending on their concentration, location, and cellular conditions. Superoxide dismutase (SOD) activities as an endogenous and exogenous cell defense mechanism include the potential use in treating various diseases, improving the potential use in treating various diseases, and improving food-stuffs preparation dietary supplements human nutrition. Published work indicates that SOD regulates oxidative stress, lipid metabolism, inflammation, and oxidation in cells. It can prevent lipid peroxidation, the oxidation of low-density lipoprotein in macrophages, lipid droplets' formation, and the adhesion of inflammatory cells into endothelial monolayers. It also expresses antioxidant effects in numerous cancer-related processes. Additionally, different forms of SOD may also augment food processing and pharmaceutical applications, exhibit anticancer, antioxidant, and anti-inflammatory effects, and prevent arterial problems by protecting the proliferation of vascular smooth muscle cells. Many investigations in this review have reported the therapeutic ability and physiological importance of SOD. Because of their antioxidative effects, SODs are of great potential in the medicinal, cosmetic, food, farming and chemical industries. This review discusses the findings of human and animal studies that support the advantages of SOD enzyme regulations to reduce the formation of oxidative stress in various ways.
许多短寿命和高反应性的氧自由基，如超氧阴离子（O）和过氧化氢（HO），在细胞中是有毒的或可能产生氧化应激，这一反应涉及到许多疾病的发病机制，具体取决于它们的浓度、位置和细胞条件。超氧化物歧化酶（SOD）作为一种内源性和外源性的细胞防御机制，具有治疗各种疾病的潜力，改善食物准备、膳食补充剂和人类营养的潜力。已发表的研究表明，SOD 调节氧化应激、脂质代谢、炎症和细胞氧化。它可以防止脂质过氧化、巨噬细胞中低密度脂蛋白的氧化、脂质滴的形成以及炎症细胞在内皮单层中的黏附。它还在许多与癌症相关的过程中表现出抗氧化作用。此外，不同形式的 SOD 也可能增强食品加工和药物应用，表现出抗癌、抗氧化和抗炎作用，并通过保护血管平滑肌细胞的增殖来预防动脉问题。本综述讨论了许多研究报告的 SOD 的治疗能力和生理重要性。由于其抗氧化作用，SOD 在医药、化妆品、食品、农业和化工行业具有巨大的潜力。本综述讨论了支持 SOD 酶调节以减少各种方式氧化应激形成的优势的人类和动物研究结果。
