Department of Neurosurgery, The First Hospital of Jilin University.
Department of Histology and Embryology, College of Basic Medical Sciences.
Int J Surg. 2024 May 1;110(5):2978-2991. doi: 10.1097/JS9.0000000000001151.
Tumor treating fields (TTFields) therapy is a novel and effective noninvasive cancer therapy, and it has been approved by FDA in the treatment of recurrent and newly diagnosed glioblastoma, and malignant pleural mesothelioma. Moreover, TTFields therapy has been widely studied in both clinical trials and preclinical studies in recent years. Based on its high efficacy, research on TTFields therapy has been a hot topic. Thus, the authors made this scientometric analysis of TTfields to reveal the scientometric distributions such as annual publications and citations, countries and institutions, authors, journals, references, and more importantly, research status and hot topics of the field. In recent years, publication numbers have been stable at high values, and citation numbers have been increasing greatly. The United States and Israel were the top two countries with the highest publication numbers, followed by Germany and Switzerland. Scientometric analyses of keywords indicated that clinical applications and antitumor mechanisms are probably the two main parts of current research on TTfields. Most clinical trials of TTfields focus on the treatment of glioblastoma. And a variety of other cancers such as lung cancer especially nonsmall cell lung cancer, hepatic cancer, other brain tumors, etc. have also been studied in both clinical trials and preclinical studies.
肿瘤治疗电场（TTFields）疗法是一种新颖且有效的非侵入性癌症疗法，已获得 FDA 批准用于治疗复发性和新诊断的胶质母细胞瘤和恶性胸膜间皮瘤。此外，近年来，TTFields 疗法在临床试验和临床前研究中都得到了广泛的研究。鉴于其高疗效，TTFields 疗法的研究一直是热门话题。因此，作者对 TTFields 进行了科学计量分析，以揭示该领域的科学计量分布，如年度出版物和引文、国家和机构、作者、期刊、参考文献等，更重要的是，揭示该领域的研究现状和热点。近年来，出版物数量一直保持在较高水平且稳定，引文数量也在大幅增加。美国和以色列是发表数量最高的两个国家，其次是德国和瑞士。关键词的科学计量分析表明，临床应用和抗肿瘤机制可能是 TTFields 目前研究的两个主要部分。TTFields 的大多数临床试验都集中在胶质母细胞瘤的治疗上。此外，在临床试验和临床前研究中，还研究了肺癌（尤其是非小细胞肺癌）、肝癌和其他脑肿瘤等多种其他癌症。
